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Peptide record

TPDB19115

Antibacterial Anticancer Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB19115
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 CAFPdb
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, and CAFPdb, with an available 3D structural model.
Sequence
FKRIVQIIKKFLR
Physicochemical Analysis
C82H141N23O15
ANDCEGHMPSTWY
IK
1689.17
12.43
5
0
7
+5
1.49
0.223
142.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
3
I
1
L
3
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 3 L: 1 K: 3 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C82H141N23O15
1689.17
12.43
+5
1.49
0.223
Evidence Records 6 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
361 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 361 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. | J Pept Sci | 2020
Evidence 2 Activity

Activity

IC50
Toxicity
27.0 µg/mL
Cytotoxic
IC50 | 27.0 | µg/mL | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. | J Pept Sci | 2020
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
292 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 292 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. | J Pept Sci | 2020
Evidence 4 Activity

Activity

IC50
Toxicity
15.7 µg/mL
Cytotoxic
IC50 | 15.7 | µg/mL | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. | J Pept Sci | 2020
Evidence 5 Activity

Activity

HC50
Toxicity
361 µg/mL
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=361 µg/ml | Cytotoxicity: DLF lung fibroblasts: IC50=27 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2020 Jul 26(7):e3254.
Evidence 6 Activity

Activity

HC50
Toxicity
292 µg/mL
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=292 µg/ml | Cytotoxicity: DLF lung fibroblasts: IC50=15.7 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2020 Jul 26(7):e3254.