TPDB

3D PDB MODEL

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TPDB ID TPDB19113

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 25-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

FIKTQVLKHLVAGVRVARGLDWKWR

FASTA

>TPDB19113|Antibacterial;Toxicity|length=25
FIKTQVLKHLVAGVRVARGLDWKWR

Formula C140H226N42O30

Absent Amino Acids NCEMPSY

Common Amino Acids V

Mass 2977.60

PI 12.14

Basic Residues 7

Acidic Residues 1

Hydrophobic Residues 13

Net Charge +5

Boman Index 1.45

Hydrophobicity 0.016

Aliphatic Index 116.80

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 369.43

Polar Residues 2

number

2

A

3

R

0

N

1

D

0

C

0

E

1

Q

2

G

1

H

1

I

3

L

3

K

0

M

1

F

0

P

0

S

1

T

2

W

0

Y

4

V

Amino Acid Distribution

A: 2 R: 3 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 2 H: 1 I: 1 L: 3 K: 3 M: 0 F: 1 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 4

Length

25

Formula

C140H226N42O30

Mass

2977.60

PI

12.14

Net Charge

+5

Boman Index

1.45

Hydrophobicity

0.016

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8 ug/ml), S.enteritidis (MIC >128 ug/ml), and S. aureus ATCC 29213 (MIC 64-128 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.enteritidis

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8 ug/ml), S.enteritidis (MIC >128 ug/ml), and S. aureus ATCC 29213 (MIC 64-128 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64-128 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8 ug/ml), S.enteritidis (MIC >128 ug/ml), and S. aureus ATCC 29213 (MIC 64-128 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022