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Peptide record

TPDB19099

Antibacterial Antifungal Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB19099
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb DRAMP dbAMP
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, DRAMP, and other sources, with an available 3D structural model.
Sequence
FIHHIIGGLFSAGKAEHRLIRRRRR
Physicochemical Analysis
C134H222N50O29
NDCQMPTWYV
R
2997.55
12.70
10
1
10
+6
5.95
-0.448
101.60
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
2
A
6
R
0
N
0
D
0
C
1
E
0
Q
3
G
3
H
4
I
2
L
1
K
0
M
2
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 3 I: 4 L: 2 K: 1 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
25
C134H222N50O29
2997.55
12.70
+6
5.95
-0.448
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
150 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 150 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. | PLoS One | 2017
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
5 %
Hemolytic
Hemolytic_activity: [Ref.29040295] 5% haemolysis at 25.00 µg/ml, 15% haemolysis at 50.00 µg/ml, 40% haemolysis at 100.00 µg/ml, 65% haemolysis at 200.00 µg/ml, 85% haemolysis at 400.00 µg/ml, 90% haemolysis at 800.00 µg/ml against mouse red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2017 Oct 17 12(10):e0186442.