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Peptide record

TPDB19092

Antibacterial Anticancer Toxicity standard

15 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB19092

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

FILYGLIRFGRLLRK

FASTA

>TPDB19092|Antibacterial;Anticancer;Toxicity|length=15
FILYGLIRFGRLLRK

Formula C91H149N25O17

Absent Amino Acids ANDCEQHMPSTWV

Common Amino Acids L

Mass 1865.34

PI 12.12

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +4

Boman Index -2.62

Hydrophobicity 0.687

Aliphatic Index 156.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 79.88

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 4 K: 1 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

Formula

C91H149N25O17

Mass

1865.34

12.12

Net Charge

Boman Index

-2.62

Hydrophobicity

0.687

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.3 µM

Target

Target Organism B. subtilis 168HT

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ B. subtilis 168HT (MIC 4.3 uM), S. aureus ST 88 (MIC 8.6 uM), S. hemolyticus 527 (MIC 8.6 uM), M. smegmatis (MIC 4.3 uM)

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.6 µM

Target

Target Organism Staphylococcus aureus ST 88

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ B. subtilis 168HT (MIC 4.3 uM), S. aureus ST 88 (MIC 8.6 uM), S. hemolyticus 527 (MIC 8.6 uM), M. smegmatis (MIC 4.3 uM), Gram- E. coli MG1655 (MIC 8.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.6 µM

Target

Target Organism S. hemolyticus 527

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ B. subtilis 168HT (MIC 4.3 uM), S. aureus ST 88 (MIC 8.6 uM), S. hemolyticus 527 (MIC 8.6 uM), M. smegmatis (MIC 4.3 uM), Gram- E. coli MG1655 (MIC 8.6 uM), K. pneumonia 148 (MIC 4.3

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.3 µM

Target

Target Organism M. smegmatis

Source & Reference

Database Source NA

Other

Evidence Text

btilis 168HT (MIC 4.3 uM), S. aureus ST 88 (MIC 8.6 uM), S. hemolyticus 527 (MIC 8.6 uM), M. smegmatis (MIC 4.3 uM), Gram- E. coli MG1655 (MIC 8.6 uM), K. pneumonia 148 (MIC 4.3 uM), K. pneumonia 50 (MIC 8

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.6 µM

Target

Target Organism Escherichia coli MG1655

Source & Reference

Database Source NA

Other

Evidence Text

eus ST 88 (MIC 8.6 uM), S. hemolyticus 527 (MIC 8.6 uM), M. smegmatis (MIC 4.3 uM), Gram- E. coli MG1655 (MIC 8.6 uM), K. pneumonia 148 (MIC 4.3 uM), K. pneumonia 50 (MIC 8.6 uM), K. pneumonia ’18-3 (MIC 8.6

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.3 µM

Target

Target Organism K. pneumonia 148

Source & Reference

Database Source NA

Other

Evidence Text

molyticus 527 (MIC 8.6 uM), M. smegmatis (MIC 4.3 uM), Gram- E. coli MG1655 (MIC 8.6 uM), K. pneumonia 148 (MIC 4.3 uM), K. pneumonia 50 (MIC 8.6 uM), K. pneumonia ’18-3 (MIC 8.6 uM), K. pneumonia 231 (MIC 8.6

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.6 µM

Target

Target Organism K. pneumonia 50

Source & Reference

Database Source NA

Other

Evidence Text

smegmatis (MIC 4.3 uM), Gram- E. coli MG1655 (MIC 8.6 uM), K. pneumonia 148 (MIC 4.3 uM), K. pneumonia 50 (MIC 8.6 uM), K. pneumonia ’18-3 (MIC 8.6 uM), K. pneumonia 231 (MIC 8.6 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.6 µM

Target

Target Organism K. pneumonia 231

Source & Reference

Database Source NA

Other

Evidence Text

neumonia 148 (MIC 4.3 uM), K. pneumonia 50 (MIC 8.6 uM), K. pneumonia ’18-3 (MIC 8.6 uM), K. pneumonia 231 (MIC 8.6 uM).

Evidence 9 Activity

Activity

Activity Endpoint LC90

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC90 | 50 | µM | target cell: Mouse fibroblasts McCoy

Target

Target Cell Mouse fibroblasts McCoy

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022

Evidence 10 Activity

Activity

Activity Endpoint LC90

Detail Source Activity Toxicity

Activity Measurement 25 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC90 | 25 | µM | target cell: Human primary fibroblasts FF1

Target

Target Cell Human primary fibroblasts FF1

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022

Evidence 11 Activity

Activity

Activity Endpoint LC90

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC90 | 50 | µM | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022

Evidence 12 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 10 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022