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Peptide record

TPDB19086

Antibacterial Antifungal Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB19086
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia Antifungipept CAFPdb DRAMP dbAMP ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.
Sequence
FIGMIPGLIGGLISAFK
Physicochemical Analysis
C84H136N18O19S1
RNDCEQHTWYV
GI
1734.17
10.10
1
0
10
+1
-3.41
1.588
143.53
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
4
I
2
L
1
K
1
M
2
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 4 L: 2 K: 1 M: 1 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C84H136N18O19S1
1734.17
10.10
+1
-3.41
1.588
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50 µM

Target

Candida albicans SC5314

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against C. albicans SC5314 (MIC 50 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C.parapsilosis ATCC 22019 (MIC 200 uM), C. neoform
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

C. tropicalis ATCC 750

Source & Reference

dbAMP DRAMP

Other

Active against C. albicans SC5314 (MIC 50 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C.parapsilosis ATCC 22019 (MIC 200 uM), C. neoformans H99 serotype A (MIC 25 uM), and C.
Evidence 3 Activity

Activity

MIC
Antibacterial
200 µM

Target

C.parapsilosis ATCC 22019

Source & Reference

dbAMP DRAMP

Other

Active against C. albicans SC5314 (MIC 50 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C.parapsilosis ATCC 22019 (MIC 200 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 u
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µM

Target

C. neoformans H99 serotype A

Source & Reference

dbAMP DRAMP

Other

MIC 50 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C.parapsilosis ATCC 22019 (MIC 200 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activ
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

C. neoformans B3501 serotype D

Source & Reference

dbAMP DRAMP

Other

M), C.parapsilosis ATCC 22019 (MIC 200 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activity against initial adherence of C. albicans at 10
Evidence 6 Activity

Activity

MIC
Antifungal
50 µM

Target

Candida albicans SC5314

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
Active against C. albicans SC5314 (MIC 50 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C.parapsilosis ATCC 22019 (MIC 200 uM), C. neoform
Evidence 7 Activity

Activity

MIC
Antifungal
12.5 µM

Target

C. tropicalis ATCC 750

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against C. albicans SC5314 (MIC 50 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C.parapsilosis ATCC 22019 (MIC 200 uM), C. neoformans H99 serotype A (MIC 25 uM), and C.
Evidence 8 Activity

Activity

MIC
Antifungal
200 µM

Target

C.parapsilosis ATCC 22019

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against C. albicans SC5314 (MIC 50 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C.parapsilosis ATCC 22019 (MIC 200 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 u
Evidence 9 Activity

Activity

MIC
Antifungal
25 µM

Target

C. neoformans H99 serotype A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

MIC 50 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C.parapsilosis ATCC 22019 (MIC 200 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activ
Evidence 10 Activity

Activity

MIC
Antifungal
12.5 µM

Target

C. neoformans B3501 serotype D

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

M), C.parapsilosis ATCC 22019 (MIC 200 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activity against initial adherence of C. albicans at 10
Evidence 11 Activity

Activity

48% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
48% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Activity of Scorpion Venom-Derived Antifungal Peptides against Planktonic Cells of Candida spp. and Cryptococcus neoformans and Candida albicans Biofilms. | Front Microbiol | 2016
Evidence 12 Activity

Activity

% Hemolysis
Toxicity
20 %
Hemolytic
Hemolytic_activity: [Ref.27917162] 20% hemolysis at 1.58 µM, 22% hemolysis at 3.16 µM, 23% hemolysis at 6.31 µM, 24% hemolysis at 12.59 µM, 28% hemolysis at 25.12 µM, 45% hemolysis at 50.11 µM , 50% hemolysis at 100µM against human red blood cell

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Microbiol. 2016 Nov 18 7:1844. eCollection 2016.