Back to search

Peptide record

TPDB19067

Antibacterial Anticancer Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB19067
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia PD_Hemolysis
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia and PD_Hemolysis, with an available 3D structural model.
Sequence
FHAWAKLLKGVGRFFKGIGRW
Physicochemical Analysis
C122H180N34O22
NDCEQMPSTY
G
2474.99
12.43
6
0
11
+5
-3.20
0.048
79.05
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11000
444.45
0
Residue Composition
number
2
A
2
R
0
N
0
D
0
C
0
E
0
Q
4
G
1
H
1
I
2
L
3
K
0
M
3
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 1 L: 2 K: 3 M: 0 F: 3 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
21
C122H180N34O22
2474.99
12.43
+5
-3.20
0.048
Evidence Records 4 records
Evidence 1 Activity

Activity

EC50
Toxicity
38.1 µM
Cytotoxic
EC50 | 38.1 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
Simulated Molecular Evolution for Anticancer Peptide Design. | Angew Chem Int Ed Engl | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
20.0±0.8 µM
Hemolytic Cytotoxic
50% Hemolysis | 20.0±0.8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Simulated Molecular Evolution for Anticancer Peptide Design. | Angew Chem Int Ed Engl | 2019
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Angew Chem Int Ed Engl. 2019 Feb 4 58(6):1674-1683.
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis