TPDB

3D PDB MODEL

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TPDB ID TPDB19062

Activity

Antibacterial

Activity_category_statistics

Anti-infective peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural antibacterial peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

FHFHLHF

FASTA

>TPDB19062|Antibacterial|length=7
FHFHLHF

Formula C51H61N13O8

Absent Amino Acids ARNDCEQGIKMPSTWYV

Common Amino Acids HF

Mass 984.13

PI 8.09

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +0

Boman Index -1.07

Hydrophobicity 0.371

Aliphatic Index 55.71

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

3

H

0

I

1

L

0

K

0

M

3

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 3 I: 0 L: 1 K: 0 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

7

Formula

C51H61N13O8

Mass

984.13

PI

8.09

Net Charge

+0

Boman Index

-1.07

Hydrophobicity

0.371

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism S. mutans

Source & Reference

Database Source NA

Other

Evidence Text

active against S. mutans (MIC 8 ug/ml), S. sanguinis (MIC 16 ug/ml), S. aureus MRSA (MIC 32 ug/ml), E. faecalis (MIC 16 ug/ml),

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism S. sanguinis

Source & Reference

Database Source NA

Other

Evidence Text

active against S. mutans (MIC 8 ug/ml), S. sanguinis (MIC 16 ug/ml), S. aureus MRSA (MIC 32 ug/ml), E. faecalis (MIC 16 ug/ml), P. aeruginosa (MIC 16 ug/ml),

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µg/mL

Target

Target Organism Staphylococcus aureus MRSA

Source & Reference

Database Source NA

Other

Evidence Text

active against S. mutans (MIC 8 ug/ml), S. sanguinis (MIC 16 ug/ml), S. aureus MRSA (MIC 32 ug/ml), E. faecalis (MIC 16 ug/ml), P. aeruginosa (MIC 16 ug/ml), and E. coli (MIC 8 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source NA

Other

Evidence Text

inst S. mutans (MIC 8 ug/ml), S. sanguinis (MIC 16 ug/ml), S. aureus MRSA (MIC 32 ug/ml), E. faecalis (MIC 16 ug/ml), P. aeruginosa (MIC 16 ug/ml), and E. coli (MIC 8 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

, S. sanguinis (MIC 16 ug/ml), S. aureus MRSA (MIC 32 ug/ml), E. faecalis (MIC 16 ug/ml), P. aeruginosa (MIC 16 ug/ml), and E. coli (MIC 8 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

aureus MRSA (MIC 32 ug/ml), E. faecalis (MIC 16 ug/ml), P. aeruginosa (MIC 16 ug/ml), and E. coli (MIC 8 ug/ml).