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Peptide record

TPDB19055

ACE inhibitor Cyclo(L-Phe-Gly) or Dipeptide 1 NDI-Phe-Gly or 2 ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Antiparasitic Antiviral Bitter Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB19055
ACE inhibitor Cyclo(L-Phe-Gly) or Dipeptide 1 NDI-Phe-Gly or 2
ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Antiparasitic Antiviral Bitter Selfassembly
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Food sensory peptides Self-assembling and biomaterial peptides
Peptipedia SATPdb CAFPdb AHTPDB AHTpin Tastepeptides-Meta SAPdb
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, SATPdb, CAFPdb, and other sources, with an available 3D structural model.
Sequence
FG
Physicochemical Analysis
C11H14N2O3
ARNDCEQHILKMPSTWYV
GF
222.24
6.02
0
0
1
-0
-1.12
1.200
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C11H14N2O3
222.24
6.02
-0
-1.12
1.200
222.2399
222.1001
Self-Assembly Information 3 records
Record 1 Selfassembly

Source

23884374
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Hydrogel Opaque Hydrogel gel (Nanofibers)
pH: 7 solvent: Phosphate buffer (pH 6) concentration: 2% w/v
Selfassembly; Nanostructure=Hydrogel; Opaque Hydrogel gel (Nanofibers); Trigger=pH: 7; solvent: Phosphate buffer (pH 6); concentration: 2% w/v
Scanning Electron Microscopy (SEM)
Selfassembly
Record 2 Selfassembly

Source

25229206
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Hydrogel
pH: 4.7 temperature: Room temperature solvent: Water concentration: 2% wt
Selfassembly; Nanostructure=Hydrogel; Trigger=pH: 4.7; temperature: Room temperature; solvent: Water; concentration: 2% wt
Transmission Electron Microscopy (TEM)
Selfassembly
Record 3 Selfassembly

Source

25229206
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Hydrogel Transparent Hydrogel
pH: 7.4 temperature: Room temperature solvent: Water concentration: 2% wt
Selfassembly; Nanostructure=Hydrogel; Transparent Hydrogel; Trigger=pH: 7.4; temperature: Room temperature; solvent: Water; concentration: 2% wt
Transmission Electron Microscopy (TEM)
Selfassembly
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
3700.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)NCC(=O)O)Cc1ccccc1 InChI=1S/C11H14N2O3/c12-9(11(16)13-7-10(14)15)6-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H,13,16)(H,14,15)/t9-/m0/s1 InChiKey: GLUBLISJVJFHQS-VIFPVBQESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.001) according to the BRENDA database Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 18), the BitterDB database, the ChEMBL database, the EROP-Moscow database (ID E03702)
Evidence 2 Activity

Activity

IC50
Antihypertensive
3700.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)NCC(=O)O)Cc1ccccc1 InChI=1S/C11H14N2O3/c12-9(11(16)13-7-10(14)15)6-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H,13,16)(H,14,15)/t9-/m0/s1 InChiKey: GLUBLISJVJFHQS-VIFPVBQESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.001) according to the BRENDA database Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 18), the BitterDB database, the ChEMBL database, the EROP-Moscow database (ID E03702)
Evidence 3 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Hydrogel Opaque Hydrogel gel (Nanofibers) Trigger=pH: 7 solvent: Phosphate buffer (pH 6) concentration: 2% w/v
Hydrogel Opaque Hydrogel gel (Nanofibers)

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 7 solvent: Phosphate buffer (pH 6) concentration: 2% w/v
Scanning Electron Microscopy (SEM)
23884374
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 4 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Hydrogel Trigger=pH: 4.7 temperature: Room temperature solvent: Water concentration: 2% wt
Hydrogel

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 4.7 temperature: Room temperature solvent: Water concentration: 2% wt
Transmission Electron Microscopy (TEM)
25229206
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 5 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Hydrogel Transparent Hydrogel Trigger=pH: 7.4 temperature: Room temperature solvent: Water concentration: 2% wt
Hydrogel Transparent Hydrogel

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 7.4 temperature: Room temperature solvent: Water concentration: 2% wt
Transmission Electron Microscopy (TEM)
25229206
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 6 fields
pH: 7 solvent: Phosphate buffer (pH 6) concentration: 2% w/v pH: 4.7 temperature: Room temperature solvent: Water concentration: 2% wt pH: 7.4
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
2
23884374 25229206
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly