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Peptide record

TPDB19037

Antibacterial Toxicity standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB19037
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia ToxinPred 3.0
standard
No
A 7-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia and ToxinPred 3.0, with an available 3D structural model.
Sequence
FFHLHFH
Physicochemical Analysis
C51H61N13O8
ARNDCEQGIKMPSTWYV
HF
984.13
8.09
3
0
4
+0
-1.07
0.371
55.71
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
3
H
0
I
1
L
0
K
0
M
3
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 3 I: 0 L: 1 K: 0 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C51H61N13O8
984.13
8.09
+0
-1.07
0.371
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

The native peptide had activity against Gram-positive S. aureus and L. monocytogenes. However, the native form appeared to be 2-3 fold more active against Gram-negative bacteria such as E. coli and P. aeruginosa.
Evidence 2 Activity

Activity

90% Hemolysis
Toxicity
10 µg/mL
Hemolytic Cytotoxic
90% Hemolysis | 10 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Plicatamide, an antimicrobial octapeptide from Styela plicata hemocytes. | J Biol Chem | 2003
Evidence 3 Activity

Activity

10% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 80 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Plicatamide, an antimicrobial octapeptide from Styela plicata hemocytes. | J Biol Chem | 2003
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human cervical epithelial cells ME-180

Target

Human cervical epithelial cells ME-180

Source & Reference

NA
DBAASP
Plicatamide, an antimicrobial octapeptide from Styela plicata hemocytes. | J Biol Chem | 2003