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Peptide record

TPDB19033

Antibacterial Antifungal standard
102 amino acids
Basic Information
3D PDB MODEL
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TPDB19033
Antibacterial Antifungal
Anti-infective peptides
Peptipedia Antifungipept
standard
No
A 102-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.
Sequence
FFSFVHEAFQGAGDMWRAYTDMKEAGWKDGDRYFHARGNYDAAQRGPGGAWAAEKISDARESFQEFFGRGHEDTMADQEANRHGRSGKDPNYYRPPGLPDKY
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C516H734N152O156S3
C
AG
11658.61
5.72
18
17
36
-3
2.84
-1.187
23.24
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
25440
2.18
19
Residue Composition
number
13
A
9
R
3
N
10
D
0
C
7
E
4
Q
13
G
4
H
1
I
1
L
5
K
3
M
8
F
5
P
4
S
2
T
3
W
6
Y
1
V
Amino Acid Distribution
A: 13 R: 9 N: 3 D: 10 C: 0 E: 7 Q: 4 G: 13 H: 4 I: 1 L: 1 K: 5 M: 3 F: 8 P: 5 S: 4 T: 2 W: 3 Y: 6 V: 1
Chemical Descriptors
102 reviewed residue count
C516H734N152O156S3 sequence-only estimate (linear, free termini)
11658.61 sequence-only estimate (linear, free termini)
5.72 sequence-only estimate (linear, free termini)
-3 sequence-only estimate (linear, free termini)
2.84 sequence-only estimate (linear, free termini)
-1.187 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

More active against E. coli and S. aureus at acidic pH 5.5. An incubation with 2.5 uM peptide reduced bacteria by 90%. Deletion of SAA1/2 in mice impaired the clearance of S. aureus in the skin. The bacterial killing of SAA at acidic pH was achieved via membrane binding and disruption ( Zheng et al., 2019 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

More active against E. coli and S. aureus at acidic pH 5.5. An incubation with 2.5 uM peptide reduced bacteria by 90%. Deletion of SAA1/2 in mice impaired the clearance of S. aureus in the skin. The bacterial killing of SAA at acidic pH was achieved via membrane binding and disruption ( Zheng et al., 2019 ).