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Peptide record

TPDB19019

Anti-inflammatory Antibacterial Anticancer Antifungal Hemolysis Toxicity standard

17 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB19019

Activity

Anti-inflammatory Antibacterial Anticancer Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Immunity and inflammation peptides Toxicity and safety peptides

Database_Source

Peptipedia CancerPPD 2.0 CAFPdb PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, CAFPdb, and other sources, with an available 3D structural model.

Sequence

FFPLIFGALSSILPKIL

FASTA

>TPDB19019|Anti-inflammatory;Antibacterial;Anticancer;Antifungal;Hemolysis;Toxicity|length=17
FFPLIFGALSSILPKIL

Formula C96H150N18O20

Absent Amino Acids RNDCEQHMTWYV

Common Amino Acids L

Mass 1876.36

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +1

Boman Index -4.57

Hydrophobicity 1.753

Aliphatic Index 166.47

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 4 K: 1 M: 0 F: 3 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C96H150N18O20

Mass

1876.36

10.10

Net Charge

Boman Index

-4.57

Hydrophobicity

1.753

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25-12.5 µM

Target

Target Organism Staphylococcus aureus ATCC 6538 or ATCC25923 or MRSA

Source & Reference

Database Source NA

Other

Evidence Text

Gram+ S. aureus ATCC 6538 or ATCC25923 or MRSA (MIC 6.25-12.5 uM), P. acnes ATCC6919 (MIC 6.25 uM), and B. subtilis CMCC63501 (MIC 6.25 uM), but not Gram-

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism P. acnes ATCC6919

Source & Reference

Database Source NA

Other

Evidence Text

Gram+ S. aureus ATCC 6538 or ATCC25923 or MRSA (MIC 6.25-12.5 uM), P. acnes ATCC6919 (MIC 6.25 uM), and B. subtilis CMCC63501 (MIC 6.25 uM), but not Gram- E.coil ATCC25922 (MIC>100 uM), P.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism B. subtilis CMCC63501

Source & Reference

Database Source NA

Other

Evidence Text

s ATCC 6538 or ATCC25923 or MRSA (MIC 6.25-12.5 uM), P. acnes ATCC6919 (MIC 6.25 uM), and B. subtilis CMCC63501 (MIC 6.25 uM), but not Gram- E.coil ATCC25922 (MIC>100 uM), P.aeruginosa ATCC 27853 (MIC>100 uM) and C.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism E.coil ATCC25922

Source & Reference

Database Source NA

Other

Evidence Text

, P. acnes ATCC6919 (MIC 6.25 uM), and B. subtilis CMCC63501 (MIC 6.25 uM), but not Gram- E.coil ATCC25922 (MIC>100 uM), P.aeruginosa ATCC 27853 (MIC>100 uM) and C.albicans CMCC 98001 (MIC >100 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism P.aeruginosa ATCC 27853

Source & Reference

Database Source NA

Other

Evidence Text

M), and B. subtilis CMCC63501 (MIC 6.25 uM), but not Gram- E.coil ATCC25922 (MIC>100 uM), P.aeruginosa ATCC 27853 (MIC>100 uM) and C.albicans CMCC 98001 (MIC >100 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism C.albicans CMCC 98001

Source & Reference

Database Source NA

Other

Evidence Text

M), but not Gram- E.coil ATCC25922 (MIC>100 uM), P.aeruginosa ATCC 27853 (MIC>100 uM) and C.albicans CMCC 98001 (MIC >100 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25-12.5 µM

Target

Target Organism Staphylococcus aureus ATCC 6538 or ATCC25923 or MRSA

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Gram+ S. aureus ATCC 6538 or ATCC25923 or MRSA (MIC 6.25-12.5 uM), P. acnes ATCC6919 (MIC 6.25 uM), and B. subtilis CMCC63501 (MIC 6.25 uM), but not Gram-

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µM

Target

Target Organism P. acnes ATCC6919

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Gram+ S. aureus ATCC 6538 or ATCC25923 or MRSA (MIC 6.25-12.5 uM), P. acnes ATCC6919 (MIC 6.25 uM), and B. subtilis CMCC63501 (MIC 6.25 uM), but not Gram- E.coil ATCC25922 (MIC>100 uM), P.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µM

Target

Target Organism B. subtilis CMCC63501

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism E.coil ATCC25922

Source & Reference

Database Source CAFPdb

Other

Evidence Text

, P. acnes ATCC6919 (MIC 6.25 uM), and B. subtilis CMCC63501 (MIC 6.25 uM), but not Gram- E.coil ATCC25922 (MIC>100 uM), P.aeruginosa ATCC 27853 (MIC>100 uM) and C.albicans CMCC 98001 (MIC >100 uM).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism P.aeruginosa ATCC 27853

Source & Reference

Database Source CAFPdb

Other

Evidence Text

M), and B. subtilis CMCC63501 (MIC 6.25 uM), but not Gram- E.coil ATCC25922 (MIC>100 uM), P.aeruginosa ATCC 27853 (MIC>100 uM) and C.albicans CMCC 98001 (MIC >100 uM).

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism C.albicans CMCC 98001

Source & Reference

Database Source CAFPdb

Other

Evidence Text

M), but not Gram- E.coil ATCC25922 (MIC>100 uM), P.aeruginosa ATCC 27853 (MIC>100 uM) and C.albicans CMCC 98001 (MIC >100 uM).

Evidence 13 Activity

Activity

Activity Endpoint 24.8% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 68.3 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

24.8% Hemolysis | 68.3 | µM | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Evaluation of antimicrobial and anticancer activities of three peptides identified from the skin secretion of Hylarana latouchii | Acta Biochim Biophys Sin | 2021

Evidence 14 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 31.4±0.7 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 31.4±0.7 | µM | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Evaluation of antimicrobial and anticancer activities of three peptides identified from the skin secretion of Hylarana latouchii | Acta Biochim Biophys Sin | 2021

Evidence 15 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Human fibroblasts MRC-5

Target

Target Cell Human fibroblasts MRC-5

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterization of a novel LTA/LPS-binding antimicrobial and anti-inflammatory temporin peptide from the skin of Fejervary limnocharis (Anura: Ranidae) | Biochem Pharmacol | 2023

Evidence 16 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Human Splenic Fibroblasts (HSF)

Target

Target Cell Human Splenic Fibroblasts (HSF)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterization of a novel LTA/LPS-binding antimicrobial and anti-inflammatory temporin peptide from the skin of Fejervary limnocharis (Anura: Ranidae) | Biochem Pharmacol | 2023

Evidence 17 Activity

Activity

Activity Endpoint 2% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 20 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

2% Hemolysis | 20 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterization of a novel LTA/LPS-binding antimicrobial and anti-inflammatory temporin peptide from the skin of Fejervary limnocharis (Anura: Ranidae) | Biochem Pharmacol | 2023

Evidence 18 Hemolysis

Source & Reference

source PD_Hemolysis

Database Source PD_Hemolysis