Back to search

Peptide record

TPDB18974

H-Phe- Phe-Phe-OH (FFF) L-Phe-L-Phe-L-Phe TriPhenylalanine Antibacterial Antihypertensive Bitter Selfassembly standard
3 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB18974
H-Phe- Phe-Phe-OH (FFF) L-Phe-L-Phe-L-Phe TriPhenylalanine
Antibacterial Antihypertensive Bitter Selfassembly
Anti-infective peptides Cardiometabolic peptides Food sensory peptides Self-assembling and biomaterial peptides
Peptipedia AHTPDB Tastepeptides-Meta SAPdb
standard
No
A 3-aa standard natural multi-activity (Antibacterial, Antihypertensive, Bitter, and other sources) peptide sequence curated from Peptipedia, AHTPDB, Tastepeptides-Meta, and other sources, with an available 3D structural model.
Sequence
FFF
Physicochemical Analysis
C27H29N3O4
ARNDCEQGHILKMPSTWYV
F
459.55
6.02
0
0
3
-0
-3.39
2.800
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
3
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C27H29N3O4
459.55
6.02
-0
-3.39
2.800
Self-Assembly Information 7 records
Record 1 Selfassembly

Source

24468750
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanosphere, Nanorod Nanospheres (in seven out of ten trajectories), Nanorods ( in the 3 out of 10 trajectories)
temperature: 37 °C solvent: Water concentration: 120 mg/ml
Selfassembly; Nanostructure=Nanosphere, Nanorod; Nanospheres (in seven out of ten trajectories), Nanorods ( in the 3 out of 10 trajectories); Trigger=temperature: 37 °C; solvent: Water; concentration: 120 mg/ml
Insilico method: MARTINI coarse - grained molecular dynamic
Selfassembly
Record 2 Selfassembly

Source

24468750
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanorod
temperature: 37 °C solvent: Water concentration: 45 mg/ml
Selfassembly; Nanostructure=Nanorod; Trigger=temperature: 37 °C; solvent: Water; concentration: 45 mg/ml
Insilico method: MARTINI coarse - grained molecular dynamic
Selfassembly
Record 3 Selfassembly

Source

24468750
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanosphere
temperature: 37 °C solvent: Water concentration: 45 mg/ml
Selfassembly; Nanostructure=Nanosphere; Trigger=temperature: 37 °C; solvent: Water; concentration: 45 mg/ml
Insilico method: MARTINI coarse - grained molecular dynamic
Selfassembly
Record 4 Selfassembly

Source

24468750
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanosphere, Nanorod Nanorods and Nanosphere
temperature: 37 °C solvent: Water concentration: 80 mg/ml
Selfassembly; Nanostructure=Nanosphere, Nanorod; Nanorods and Nanosphere; Trigger=temperature: 37 °C; solvent: Water; concentration: 80 mg/ml
Insilico method: MARTINI coarse - grained molecular dynamic
Selfassembly
Record 5 Selfassembly

Source

30968092
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanostructure nanostructures
pH: 4.9-5.2 temperature: 230℃ solvent: HFIP concentration: 10 μL
Selfassembly; Nanostructure=Nanostructure; nanostructures; Trigger=pH: 4.9-5.2; temperature: 230℃; solvent: HFIP; concentration: 10 μL
SEM, TG, VCD, and solid-state NMR
Selfassembly
Record 6 Selfassembly

Source

28955776
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanostructure nanostructured aggregates
pH: 7.4 solvent: Tris-NaCl EDTA (TNE) buffer
Selfassembly; Nanostructure=Nanostructure; nanostructured aggregates; Trigger=pH: 7.4; solvent: Tris-NaCl EDTA (TNE) buffer
ultraviolet (UV) absorption spectroscopy, fluorescence spectroscopy and circular dichroism (CD) spectroscopy
Selfassembly
Record 7 Selfassembly

Source

19527662
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Plate like Nano-structure
temperature: Room temperature solvent: Chlorinated alcohol concentration: 2mg/ml
Selfassembly; Nanostructure=Plate like Nano-structure; Trigger=temperature: Room temperature; solvent: Chlorinated alcohol; concentration: 2mg/ml
Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM) and FTIR (Fourier Transform Infrared)
Selfassembly
Evidence Records 8 records
Evidence 1 Activity

Source & Reference

AHTPDB Tastepeptides-Meta
Evidence 2 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanosphere, Nanorod Nanospheres (in seven out of ten trajectories), Nanorods ( in the 3 out of 10 trajectories) Trigger=temperature: 37 °C solvent: Water concentration: 120 mg/ml
Nanosphere, Nanorod Nanospheres (in seven out of ten trajectories), Nanorods ( in the 3 out of 10 trajectories)

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: 37 °C solvent: Water concentration: 120 mg/ml
Insilico method: MARTINI coarse - grained molecular dynamic
24468750
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 3 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanorod Trigger=temperature: 37 °C solvent: Water concentration: 45 mg/ml
Nanorod

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: 37 °C solvent: Water concentration: 45 mg/ml
Insilico method: MARTINI coarse - grained molecular dynamic
24468750
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 4 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanosphere Trigger=temperature: 37 °C solvent: Water concentration: 45 mg/ml
Nanosphere

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: 37 °C solvent: Water concentration: 45 mg/ml
Insilico method: MARTINI coarse - grained molecular dynamic
24468750
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 5 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanosphere, Nanorod Nanorods and Nanosphere Trigger=temperature: 37 °C solvent: Water concentration: 80 mg/ml
Nanosphere, Nanorod Nanorods and Nanosphere

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: 37 °C solvent: Water concentration: 80 mg/ml
Insilico method: MARTINI coarse - grained molecular dynamic
24468750
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 6 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanostructure nanostructures Trigger=pH: 4.9-5.2 temperature: 230℃ solvent: HFIP concentration: 10 μL
Nanostructure nanostructures

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 4.9-5.2 temperature: 230℃ solvent: HFIP concentration: 10 μL
SEM, TG, VCD, and solid-state NMR
30968092
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 7 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanostructure nanostructured aggregates Trigger=pH: 7.4 solvent: Tris-NaCl EDTA (TNE) buffer
Nanostructure nanostructured aggregates

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 7.4 solvent: Tris-NaCl EDTA (TNE) buffer
ultraviolet (UV) absorption spectroscopy, fluorescence spectroscopy and circular dichroism (CD) spectroscopy
28955776
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 8 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Plate like Nano-structure Trigger=temperature: Room temperature solvent: Chlorinated alcohol concentration: 2mg/ml
Plate like Nano-structure

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: Chlorinated alcohol concentration: 2mg/ml
Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM) and FTIR (Fourier Transform Infrared)
19527662
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1179 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Additional Detail Fields 5 fields
temperature: 37 °C solvent: Water concentration: 120 mg/ml concentration: 45 mg/ml concentration: 80 mg/ml pH: 4.9-5.2 temperature: 230℃ solvent: HFIP concentration: 10 μL pH: 7.4 solvent: Tris-NaCl EDTA (TNE) buffer temperature: Room temperature solvent: Chlorinated alcohol concentration: 2mg/ml
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database. SAPdb ID 1179 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
24468750 30968092 28955776 19527662
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly