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Peptide record

TPDB18939

AC-P19M Antibacterial Anticancer Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB18939
AC-P19M
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
Sequence
FAKKLAKLKKKLAKLAKKR
Physicochemical Analysis
C105H195N31O20
NDCEQGHIMPSTWYV
K
2211.90
12.00
10
0
9
+10
5.67
-0.758
103.16
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
4
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
9
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 9 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
19
C105H195N31O20
2211.90
12.00
+10
5.67
-0.758
Free
L
Linear
Free
Anticancer and Antimicrobial
Synthetic analogue of AC-P19
Evidence Records 7 records
Evidence 1 Activity

Activity

IC50
IC50 = 9.84 µM
Anticancer
9.84 µM

Target

Lung Cancer
A-549
Lung

Assay & Model

WST-8 assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 6.29 µM
Anticancer
6.29 µM

Target

Lung Cancer
H-460
Lung

Assay & Model

WST-8 assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 3 Activity

Activity

IC50
Toxicity
75 µM
Cytotoxic
IC50 | 75 | µM | target cell: Human bronchial epithelial cells BEAS-2B

Target

Human bronchial epithelial cells BEAS-2B

Source & Reference

NA
DBAASP
De Novo Design of AC-P19M, a Novel Anticancer Peptide with Apoptotic Effects on Lung Cancer Cells and Anti-Angiogenic Activity. | Int J Mol Sci | 2022
Evidence 4 Activity

Activity

IC50
Toxicity
50 µM
Cytotoxic
IC50 | 50 | µM | target cell: Human adipose-derived mesenchymal cells ADMSC

Target

Human adipose-derived mesenchymal cells ADMSC

Source & Reference

NA
DBAASP
De Novo Design of AC-P19M, a Novel Anticancer Peptide with Apoptotic Effects on Lung Cancer Cells and Anti-Angiogenic Activity. | Int J Mol Sci | 2022
Evidence 5 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
De Novo Design of AC-P19M, a Novel Anticancer Peptide with Apoptotic Effects on Lung Cancer Cells and Anti-Angiogenic Activity. | Int J Mol Sci | 2022
Evidence 6 Activity

Activity

10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
10% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De Novo Design of AC-P19M, a Novel Anticancer Peptide with Apoptotic Effects on Lung Cancer Cells and Anti-Angiogenic Activity. | Int J Mol Sci | 2022
Evidence 7 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2022 Dec 9 23(24):15595.