Back to search

Peptide record

TPDB18933

Antibacterial Antifungal standard
22 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB18933
Antibacterial Antifungal
Anti-infective peptides
Peptipedia Antifungipept
standard
No
A 22-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.
Sequence
FAHWPDLGPGSPSVKKHGKVIM
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C111H170N30O27S1
RNCEQTY
GKP
2388.82
10.32
5
1
8
+2
0.51
-0.314
66.36
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
2.30
2
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
3
G
2
H
1
I
1
L
3
K
1
M
1
F
3
P
2
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 3 H: 2 I: 1 L: 1 K: 3 M: 1 F: 1 P: 3 S: 2 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
22 reviewed residue count
C111H170N30O27S1 sequence-only estimate (linear, free termini)
2388.82 sequence-only estimate (linear, free termini)
10.32 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
0.51 sequence-only estimate (linear, free termini)
-0.314 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Active against E. tarda. At 83.72 uM, it killed S. aureus, M. lysodeikticus, E. tarda and V. harveyi (MBC 83.72 uM) at 41.86 uM, it killed A. caviae, A. hydrophila, 70% A. jandaei, A. veronil, V. alginolyticus, and V. parahaemolyticus (MBC 41.86 uM). Replaced 12/2017 updated 7/2021 .
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

Active against E. tarda. At 83.72 uM, it killed S. aureus, M. lysodeikticus, E. tarda and V. harveyi (MBC 83.72 uM) at 41.86 uM, it killed A. caviae, A. hydrophila, 70% A. jandaei, A. veronil, V. alginolyticus, and V. parahaemolyticus (MBC 41.86 uM). Replaced 12/2017 updated 7/2021 .