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Peptide record

TPDB18928

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB18928
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
FACPIGFFRLKR
Physicochemical Analysis
C70H107N19O13S1
NDEQHMSTWYV
F
1454.80
11.32
3
0
6
+3
-1.60
0.508
73.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
2
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
1
I
1
L
1
K
0
M
3
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 1 M: 0 F: 3 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C70H107N19O13S1
1454.80
11.32
+3
-1.60
0.508
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
88 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

weakly active against E. coli ATCC 25922 (MIC 88 uM), S.enteritidis (MIC >128 ug/ml), S.aureus ATCC 29213 (MIC > 128 ug/ml).
Evidence 2 Activity

Activity

MIC
Antibacterial
>128 µg/mL

Target

S.enteritidis

Source & Reference

NA

Other

weakly active against E. coli ATCC 25922 (MIC 88 uM), S.enteritidis (MIC >128 ug/ml), S.aureus ATCC 29213 (MIC > 128 ug/ml).
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
>128 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022