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Peptide record

TPDB18847

Neurotensin NT4 Anti-inflammatory Antibacterial Antifungal Blood-Brain Barrier Tumor-homing Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB18847
Neurotensin NT4
Anti-inflammatory Antibacterial Antifungal Blood-Brain Barrier Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Immunity and inflammation peptides Delivery and barrier-penetrating peptides
Peptipedia CAFPdb B3Pred BBPpredict TumorHoPe2.0
standard
No
A 13-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, B3Pred, and other sources, with an available 3D structural model.
Sequence
ELYENKPRRPYIL
Physicochemical Analysis
C78H123N21O21
ADCQGHMFSTWV
RELPY
1690.96
9.56
3
2
5
+1
4.66
-1.315
90.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
2980
176.23
3
Residue Composition
number
0
A
2
R
1
N
0
D
0
C
2
E
0
Q
0
G
0
H
1
I
2
L
1
K
0
M
0
F
2
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
13
C78H123N21O21
1690.96
9.56
+1
4.66
-1.315
1690.9344
Tridecapeptide
1689.9174
Similarity
pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH
N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Evidence Records 5 records
Evidence 1 Activity

Activity

EC50
Anti-inflammatory
0.00 µM
anti inflammatory
ai

Source & Reference

NA
Wei E. T., Thomas H. A.
Anti-inflammatory peptide agonists. Annu. Rev. Pharmacol. Toxicol., 33, 91-108
1993
Journal

Other

13
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(O)=O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C78H123N21O21/c1-7-43(6)63(73(116)96-57(76(119)120)37-42(4)5)97-70(113)55(39-45-21-25-47(101)26-22-45)95-72(115)59-18-13-35-99(59)75(118)52(16-11-33-87-78(84)85)90-65(108)49(15-10-32-86-77(82)83)89-71(114)58-17-12-34-98(58)74(117)51(14-8-9-31-79)91-69(112)56(40-60(81)102)94-66(109)50(28-30-62(105)106)88-68(111)54(38-44-19-23-46(100)24-20-44)93-67(110)53(36-41(2)3)92-64(107)48(80)27-29-61(103)104/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79-80H2,1-6H3,(H2,81,102)(H,88,111)(H,89,114)(H,90,108)(H,91,112)(H,92,107)(H,93,110)(H,94,109)(H,95,115)(H,96,116)(H,97,113)(H,103,104)(H,105,106)(H,119,120)(H4,82,83,86)(H4,84,85,87)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1 InChIKey=UKJYWRYJTVYJRZ-ISULXFBGSA-N
Evidence 2 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source
Student's t-test (two-tailed) and Mann-Whitney U-test

Source & Reference

NA
B3Pdb

Other

bovine hypothalamus
Not able to cross the BBB in sufficient quantities to exert direct brain effects. Can modify the sed
Evidence 3 Activity

Activity

Blood-Brain Barrier

Assay & Model

Adult male Swiss-Webster mice
Origin/Source

Source & Reference

NA
B3Pdb

Other

bovine hypothalamus
Not able to cross the BBB in sufficient quantities to exert direct brain effects. Can modify the sed
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Triple-negative Breast cancer (TNBC)
Heparan sulfate proteoglycans (HSPGs)(syndecans and glypicans)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Endocytosis and Trafficking of Heparan Sulfate Proteoglycans in Triple-Negative Breast Cancer Cells Unraveled with a Polycationic Peptide
2020
Elisabetta Mandarini et al. Int J Mol Sci. 2020 Nov 5 21(21):8282.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
MDA-MB-231 human breast cancer cells
Synthetic
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Colon adenocarcinoma, pancreas adenocarcinoma, bladder cancer, Breast cancer
Sulfated Glycosaminoglycans (sulfated GAGs)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Heparan Sulfate Proteoglycans Can Promote Opposite Effects on Adhesion and Directional Migration of Different Cancer Cells
2020
Lorenzo Depau et al. J Med Chem. 2020 Dec 24 63(24):15997-16011.

Other

PANC-1 human pancreas adenocarcinoma, HT29 colon adenocarcinoma, T24 bladder carcinoma, A375 melanoma, MDA-MB 231 breast adenocarcinoma, MCF7 breast adenocarcinoma, TE671 rhabdomyosarcoma cells
Synthetic
Additional Detail Fields 2 fields
MDA-MB-231 human breast cancer cells PANC-1 human pancreas adenocarcinoma, HT29 colon adenocarcinoma, T24 bladder carcinoma, A375 melanoma, MDA-MB 231 breast adenocarcinoma, MCF7 breast adenocarcinoma, TE671 rhabdomyosarcoma cells
13