Back to search

Peptide record

TPDB18831

ACE inhibitor (beta-CN 108-113) ACE inhibitors Antibacterial Antidiabetic Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB18831
ACE inhibitor (beta-CN 108-113)
ACE inhibitors Antibacterial Antidiabetic Antihypertensive
Anti-infective peptides Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antidiabetic, and other sources) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
EMPFPK
Physicochemical Analysis
C35H53N7O9S1
ARNDCQGHILSTWYV
P
747.91
6.94
1
1
2
-0
2.55
-0.983
0.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
1
K
1
M
1
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 1 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C35H53N7O9S1
747.91
6.94
-0
2.55
-0.983
747.9008
747.3613
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
423.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Pihlanto-Leppala A., Rokka T., Korhonen H.
Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy J., 8, 325-331, 1998
1998
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(O)=O)C(=O)N[C@@]([H])(CCSC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C35H53N7O9S/c1-52-20-16-24(38-30(45)23(37)14-15-29(43)44)33(48)41-18-7-13-28(41)32(47)40-26(21-22-9-3-2-4-10-22)34(49)42-19-8-12-27(42)31(46)39-25(35(50)51)11-5-6-17-36/h2-4,9-10,23-28H,5-8,11-21,36-37H2,1H3,(H,38,45)(H,39,46)(H,40,47)(H,43,44)(H,50,51)/t23-,24-,25-,26-,27-,28-/m0/s1 InChIKey=YYPXQEBSTDDIIK-QUQVWLGBSA-N Peptide stimulating mucin secretion according to the BIOPEP-UWM database of bioactive peptides (ID 9745) the MBPDB database Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9771) the EROP-Moscow database the MBPDB database the MilkAMP database
Evidence 2 Activity

Activity

IC50
Antihypertensive
423.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Pihlanto-Leppala A., Rokka T., Korhonen H.
Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy J., 8, 325-331, 1998
1998
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(O)=O)C(=O)N[C@@]([H])(CCSC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C35H53N7O9S/c1-52-20-16-24(38-30(45)23(37)14-15-29(43)44)33(48)41-18-7-13-28(41)32(47)40-26(21-22-9-3-2-4-10-22)34(49)42-19-8-12-27(42)31(46)39-25(35(50)51)11-5-6-17-36/h2-4,9-10,23-28H,5-8,11-21,36-37H2,1H3,(H,38,45)(H,39,46)(H,40,47)(H,43,44)(H,50,51)/t23-,24-,25-,26-,27-,28-/m0/s1 InChIKey=YYPXQEBSTDDIIK-QUQVWLGBSA-N Peptide stimulating mucin secretion according to the BIOPEP-UWM database of bioactive peptides (ID 9745) the MBPDB database Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9771) the EROP-Moscow database the MBPDB database the MilkAMP database
Additional Detail Fields 1 fields
6