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Peptide record

TPDB18809

Antibacterial Anticancer Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB18809
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
EKRWRRLIFNYF
Physicochemical Analysis
C83H122N24O17
ADCQGHMPSTV
R
1728.03
11.30
4
1
6
+3
-0.06
-1.058
65.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
6990
404.51
2
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
1
E
0
Q
0
G
0
H
1
I
1
L
1
K
0
M
2
F
0
P
0
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
12
C83H122N24O17
1728.03
11.30
+3
-0.06
-1.058
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
9.3 µM

Target

B. subtilis 168HT

Source & Reference

NA

Other

Active against Gram+ B. subtilis 168HT (MIC 9.3 uM), S. aureus ST 88 (MIC 18.5 uM), S. hemolyticus 527 (MIC 4.6 uM), M. smegmatis (MIC 18.5 u
Evidence 2 Activity

Activity

MIC
Antibacterial
18.5 µM

Target

Staphylococcus aureus ST 88

Source & Reference

NA

Other

Active against Gram+ B. subtilis 168HT (MIC 9.3 uM), S. aureus ST 88 (MIC 18.5 uM), S. hemolyticus 527 (MIC 4.6 uM), M. smegmatis (MIC 18.5 uM), Gram- E. coli MG1655 (MIC 4
Evidence 3 Activity

Activity

MIC
Antibacterial
4.6 µM

Target

S. hemolyticus 527

Source & Reference

NA

Other

Active against Gram+ B. subtilis 168HT (MIC 9.3 uM), S. aureus ST 88 (MIC 18.5 uM), S. hemolyticus 527 (MIC 4.6 uM), M. smegmatis (MIC 18.5 uM), Gram- E. coli MG1655 (MIC 4.6 uM), K. pneumonia 148 (MIC 9.3
Evidence 4 Activity

Activity

MIC
Antibacterial
18.5 µM

Target

M. smegmatis

Source & Reference

NA

Other

tilis 168HT (MIC 9.3 uM), S. aureus ST 88 (MIC 18.5 uM), S. hemolyticus 527 (MIC 4.6 uM), M. smegmatis (MIC 18.5 uM), Gram- E. coli MG1655 (MIC 4.6 uM), K. pneumonia 148 (MIC 9.3 uM), K. pneumonia 50 (MIC 1
Evidence 5 Activity

Activity

MIC
Antibacterial
4.6 µM

Target

Escherichia coli MG1655

Source & Reference

NA

Other

s ST 88 (MIC 18.5 uM), S. hemolyticus 527 (MIC 4.6 uM), M. smegmatis (MIC 18.5 uM), Gram- E. coli MG1655 (MIC 4.6 uM), K. pneumonia 148 (MIC 9.3 uM), K. pneumonia 50 (MIC 18.5 uM), K. pneumonia ’18-3 (MIC 18
Evidence 6 Activity

Activity

MIC
Antibacterial
9.3 µM

Target

K. pneumonia 148

Source & Reference

NA

Other

olyticus 527 (MIC 4.6 uM), M. smegmatis (MIC 18.5 uM), Gram- E. coli MG1655 (MIC 4.6 uM), K. pneumonia 148 (MIC 9.3 uM), K. pneumonia 50 (MIC 18.5 uM), K. pneumonia ’18-3 (MIC 18.5 uM), K. pneumonia 231 (MIC 1
Evidence 7 Activity

Activity

MIC
Antibacterial
18.5 µM

Target

K. pneumonia 50

Source & Reference

NA

Other

megmatis (MIC 18.5 uM), Gram- E. coli MG1655 (MIC 4.6 uM), K. pneumonia 148 (MIC 9.3 uM), K. pneumonia 50 (MIC 18.5 uM), K. pneumonia ’18-3 (MIC 18.5 uM), K. pneumonia 231 (MIC 18.5 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
18.5 µM

Target

K. pneumonia 231

Source & Reference

NA

Other

umonia 148 (MIC 9.3 uM), K. pneumonia 50 (MIC 18.5 uM), K. pneumonia ’18-3 (MIC 18.5 uM), K. pneumonia 231 (MIC 18.5 uM).
Evidence 9 Activity

Activity

LC90
Toxicity
>100 µM
Cytotoxic
LC90 | >100 | µM | target cell: Mouse fibroblasts McCoy

Target

Mouse fibroblasts McCoy

Source & Reference

NA
DBAASP
Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022
Evidence 10 Activity

Activity

LC90
Toxicity
>100 µM
Cytotoxic
LC90 | >100 | µM | target cell: Human primary fibroblasts FF1

Target

Human primary fibroblasts FF1

Source & Reference

NA
DBAASP
Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022
Evidence 11 Activity

Activity

LC90
Toxicity
>100 µM
Cytotoxic
LC90 | >100 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022
Evidence 12 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022