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Peptide record

TPDB18752

ACE inhibitor ACE inhibitors Antibacterial Antiviral Bitter Toxicity standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB18752
ACE inhibitor
ACE inhibitors Antibacterial Antiviral Bitter Toxicity
Anti-infective peptides Cardiometabolic peptides Toxicity and safety peptides Food sensory peptides
Peptipedia dbAMP 3.0 DRAVP 2.0 Tastepeptides-Meta
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antiviral, and other sources) peptide sequence curated from Peptipedia, dbAMP 3.0, DRAVP 2.0, and other sources, with an available 3D structural model.
Sequence
EF
Physicochemical Analysis
C14H18N2O5
ARNDCQGHILKMPSTWYV
EF
294.31
3.29
0
1
1
-1
0.89
-0.350
0.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C14H18N2O5
294.31
3.29
-1
0.89
-0.350
294.3024
294.1211
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Li, H., Aluko, R.E.
Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem. 58, 11471-11476, 2010
2010
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI= 1S/C14H18N2O5/c15-10(6-7-12(17)18)13(19)16-11(14(20)21)8-9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H,16,19)(H,17,18)(H,20,21)/t10-,11-/m0/s1 InChIKey: XMBSYZWANAQXEV-QWRGUYRKSA-N Inhibitor of calmodulin-dependent phosphodiesterase 1 (abbrev. CaMPDE) (EC 3.1.4.17) according to BIOPEP-UWM database of bioactive peptides (ID 8250) Inhibitor of Aminopeptidase A (EC 3.4.11.7) (MEROPS ID: M01.003) according to the BRENDA database Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 8250) Hypolipidemic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9580) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 274) Sour peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 524)
Evidence 2 Activity

Activity

0% Cytotoxicity
Toxicity
500 µM
Cytotoxic
0% Cytotoxicity | 500 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Peptide inhibitors against dengue virus infection. | Chem Biol Drug Des | 2014
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.24612829]No cytotoxicity against Vero cells up to 500 µM.

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2014 Aug 84(2):148-57.
Additional Detail Fields 1 fields
2