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Peptide record

TPDB18616

Antibacterial Anticancer Antifungal Toxicity standard
60 amino acids
Basic Information
3D PDB MODEL
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TPDB18616
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
standard
No
A 60-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Sequence
DSEGWKVQPNINRDQDGNTAGSVRVQKQLGNHEVHAGASRVFSGPNRGGPSYNVGATFNW
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C277H421N91O90
CM
G
6465.95
9.65
8
5
17
+1
2.51
-0.980
48.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
12490
1.93
19
Residue Composition
number
4
A
4
R
7
N
3
D
0
C
2
E
4
Q
9
G
2
H
1
I
1
L
2
K
0
M
2
F
3
P
5
S
2
T
2
W
1
Y
6
V
Amino Acid Distribution
A: 4 R: 4 N: 7 D: 3 C: 0 E: 2 Q: 4 G: 9 H: 2 I: 1 L: 1 K: 2 M: 0 F: 2 P: 3 S: 5 T: 2 W: 2 Y: 1 V: 6
Chemical Descriptors
60 reviewed residue count
C277H421N91O90 sequence-only estimate (linear, free termini)
6465.95 sequence-only estimate (linear, free termini)
9.65 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
2.51 sequence-only estimate (linear, free termini)
-0.980 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Biological Profiling of Coleoptericins and Coleoptericin-Like Antimicrobial Peptides from the Invasive Harlequin Ladybird Harmonia axyridis. | Adv Exp Med Biol | 2018