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Peptide record

TPDB18588

Antibacterial Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB18588
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 29-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
DLTTKLWSSWGYYLGKKARWNLKHPYVQF
Physicochemical Analysis
C173H249N43O41
CEIM
LK
3587.14
10.24
6
1
13
+4
-2.87
-0.752
67.24
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
20970
584.59
9
Residue Composition
number
1
A
1
R
1
N
1
D
0
C
0
E
1
Q
2
G
1
H
0
I
4
L
4
K
0
M
1
F
1
P
2
S
2
T
3
W
3
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 2 H: 1 I: 0 L: 4 K: 4 M: 0 F: 1 P: 1 S: 2 T: 2 W: 3 Y: 3 V: 1
Chemical Descriptors
29
C173H249N43O41
3587.14
10.24
+4
-2.87
-0.752
Evidence Records 4 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
0% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Plantaricin NC8 alpha beta Exerts Potent Antimicrobial Activity Against Staphylococcus Spp. And Enhances the Effects of Antibiotics. | Sci Rep | 2020
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Plantaricin NC8 alpha beta Exerts Potent Antimicrobial Activity Against Staphylococcus Spp. And Enhances the Effects of Antibiotics. | Sci Rep | 2020
Evidence 3 Activity

Activity

9.8% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
9.8% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Plantaricin NC8 alpha beta Exerts Potent Antimicrobial Activity Against Staphylococcus Spp. And Enhances the Effects of Antibiotics. | Sci Rep | 2020
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
NA | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Plantaricin NC8 alpha beta Exerts Potent Antimicrobial Activity Against Staphylococcus Spp. And Enhances the Effects of Antibiotics. | Sci Rep | 2020