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Peptide record

TPDB18551

Antibacterial Anticancer Antifungal Antiparasitic standard
54 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB18551
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
Peptipedia ACP740 _ACP240 AFP-GFuse Antifungipept CAFPdb DRAMP dbAMP i2APP
standard
No
A 54-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, ACP740 _ACP240, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
DGVKLCDVPSGTWSGHCGSSSKCSQQCKDREHFAYGGACHYQFPSVKCFCKRQC
Physicochemical Analysis
C251H378N76O77S8
NIM
C
5948.71
8.10
10
4
12
+3
9.76
-0.613
27.04
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
8980
150.96
22
Residue Composition
number
2
A
2
R
0
N
3
D
8
C
1
E
4
Q
6
G
3
H
0
I
1
L
5
K
0
M
3
F
2
P
7
S
1
T
1
W
2
Y
3
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 3 C: 8 E: 1 Q: 4 G: 6 H: 3 I: 0 L: 1 K: 5 M: 0 F: 3 P: 2 S: 7 T: 1 W: 1 Y: 2 V: 3
Chemical Descriptors
54
C251H378N76O77S8
5948.71
8.10
+3
9.76
-0.613
Evidence Records 24 records
Evidence 1 Activity

Activity

IC50
Antibacterial
6 µg/mL

Target

B. cinerea

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
medium A supplemented with 1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 6 ug/ml), C. sphaerospermum (IC50 1 ug/ml), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml
Evidence 2 Activity

Activity

IC50
Antibacterial
1 µg/mL

Target

C. sphaerospermum

Source & Reference

dbAMP DRAMP

Other

1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 6 ug/ml), C. sphaerospermum (IC50 1 ug/ml), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T.
Evidence 3 Activity

Activity

IC50
Antibacterial
1 µg/mL

Target

F. culmorum

Source & Reference

dbAMP DRAMP

Other

tide is active against fungi B. cinerea (IC50 6 ug/ml), C. sphaerospermum (IC50 1 ug/ml), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S.
Evidence 4 Activity

Activity

IC50
Antibacterial
25 µg/mL

Target

L. maculans

Source & Reference

dbAMP DRAMP

Other

B. cinerea (IC50 6 ug/ml), C. sphaerospermum (IC50 1 ug/ml), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S. tritici (IC50 0.5 ug/ml), and
Evidence 5 Activity

Activity

IC50
Antibacterial
1 µg/mL

Target

P. digitatum

Source & Reference

dbAMP DRAMP

Other

. sphaerospermum (IC50 1 ug/ml), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S. tritici (IC50 0.5 ug/ml), and V. albo-atrum (IC50 12 ug/ml
Evidence 6 Activity

Activity

IC50
Antibacterial
15 µg/mL

Target

T. viride

Source & Reference

dbAMP DRAMP

Other

l), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S. tritici (IC50 0.5 ug/ml), and V. albo-atrum (IC50 12 ug/ml) (FEBS Lett. 1995 Jul 17 3
Evidence 7 Activity

Activity

IC50
Antibacterial
0.5 µg/mL

Target

S. tritici

Source & Reference

dbAMP DRAMP

Other

ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S. tritici (IC50 0.5 ug/ml), and V. albo-atrum (IC50 12 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). Both non-germi
Evidence 8 Activity

Activity

IC50
Antibacterial
12 µg/mL

Target

V. albo-atrum

Source & Reference

dbAMP DRAMP

Other

P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S. tritici (IC50 0.5 ug/ml), and V. albo-atrum (IC50 12 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). Both non-germinated and germinated conidia of F.
Evidence 9 Activity

Activity

IC50
Antifungal
6 µg/mL

Target

B. cinerea

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
medium A supplemented with 1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 6 ug/ml), C. sphaerospermum (IC50 1 ug/ml), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml
Evidence 10 Activity

Activity

IC50
Antifungal
1 µg/mL

Target

C. sphaerospermum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 6 ug/ml), C. sphaerospermum (IC50 1 ug/ml), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T.
Evidence 11 Activity

Activity

IC50
Antifungal
1 µg/mL

Target

F. culmorum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

tide is active against fungi B. cinerea (IC50 6 ug/ml), C. sphaerospermum (IC50 1 ug/ml), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S.
Evidence 12 Activity

Activity

IC50
Antifungal
25 µg/mL

Target

L. maculans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

B. cinerea (IC50 6 ug/ml), C. sphaerospermum (IC50 1 ug/ml), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S. tritici (IC50 0.5 ug/ml), and
Evidence 13 Activity

Activity

IC50
Antifungal
1 µg/mL

Target

P. digitatum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. sphaerospermum (IC50 1 ug/ml), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S. tritici (IC50 0.5 ug/ml), and V. albo-atrum (IC50 12 ug/ml
Evidence 14 Activity

Activity

IC50
Antifungal
15 µg/mL

Target

T. viride

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

l), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S. tritici (IC50 0.5 ug/ml), and V. albo-atrum (IC50 12 ug/ml) (FEBS Lett. 1995 Jul 17 3
Evidence 15 Activity

Activity

IC50
Antifungal
0.5 µg/mL

Target

S. tritici

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S. tritici (IC50 0.5 ug/ml), and V. albo-atrum (IC50 12 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). Both non-germi
Evidence 16 Activity

Activity

IC50
Antifungal
12 µg/mL

Target

V. albo-atrum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S. tritici (IC50 0.5 ug/ml), and V. albo-atrum (IC50 12 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). Both non-germinated and germinated conidia of F.
Evidence 17 Activity

Activity

IC50
Antiparasitic
6 µg/mL

Target

B. cinerea

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
medium A supplemented with 1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 6 ug/ml), C. sphaerospermum (IC50 1 ug/ml), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml
Evidence 18 Activity

Activity

IC50
Antiparasitic
1 µg/mL

Target

C. sphaerospermum

Source & Reference

DRAMP

Other

1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 6 ug/ml), C. sphaerospermum (IC50 1 ug/ml), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T.
Evidence 19 Activity

Activity

IC50
Antiparasitic
1 µg/mL

Target

F. culmorum

Source & Reference

DRAMP

Other

tide is active against fungi B. cinerea (IC50 6 ug/ml), C. sphaerospermum (IC50 1 ug/ml), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S.
Evidence 20 Activity

Activity

IC50
Antiparasitic
25 µg/mL

Target

L. maculans

Source & Reference

DRAMP

Other

B. cinerea (IC50 6 ug/ml), C. sphaerospermum (IC50 1 ug/ml), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S. tritici (IC50 0.5 ug/ml), and
Evidence 21 Activity

Activity

IC50
Antiparasitic
1 µg/mL

Target

P. digitatum

Source & Reference

DRAMP

Other

. sphaerospermum (IC50 1 ug/ml), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S. tritici (IC50 0.5 ug/ml), and V. albo-atrum (IC50 12 ug/ml
Evidence 22 Activity

Activity

IC50
Antiparasitic
15 µg/mL

Target

T. viride

Source & Reference

DRAMP

Other

l), F. culmorum (IC50 1 ug/ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S. tritici (IC50 0.5 ug/ml), and V. albo-atrum (IC50 12 ug/ml) (FEBS Lett. 1995 Jul 17 3
Evidence 23 Activity

Activity

IC50
Antiparasitic
0.5 µg/mL

Target

S. tritici

Source & Reference

DRAMP

Other

ml), L. maculans (IC50 25 ug/ml), P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S. tritici (IC50 0.5 ug/ml), and V. albo-atrum (IC50 12 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). Both non-germi
Evidence 24 Activity

Activity

IC50
Antiparasitic
12 µg/mL

Target

V. albo-atrum

Source & Reference

DRAMP

Other

P. digitatum (IC50 1 ug/ml), T. viride (IC50 15 ug/ml), S. tritici (IC50 0.5 ug/ml), and V. albo-atrum (IC50 12 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). Both non-germinated and germinated conidia of F.