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Peptide record

TPDB18533

XLAsp-P1 Antibacterial Anticancer Toxicity standard

5 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB18533

Peptide_Name

XLAsp-P1

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia CancerPPD 2.0 dbACP dbAMP 3.0 ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, CancerPPD 2.0, dbACP, and other sources, with an available 3D structural model.

Sequence

DEDDD

FASTA

>TPDB18533|Antibacterial;Anticancer;Toxicity|length=5
DEDDD

Formula C21H29N5O16

Absent Amino Acids ARNCQGHILKMFPSTWYV

Common Amino Acids D

Mass 607.49

PI 2.72

Basic Residues 0

Acidic Residues 5

Hydrophobic Residues 0

Net Charge -5

Boman Index 6.94

Hydrophobicity -3.500

Aliphatic Index 0.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 4 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C21H29N5O16

Mass

607.49

2.72

Net Charge

-5

Boman Index

6.94

Hydrophobicity

-3.500

C_terminal_Modification

Free

Chirality

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Xenopus laevis

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µg/mL

Target

Target Organism Staphylococcus aureus ATC29213

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ bacteria S. aureus ATC29213 (MIC 10 ug/ml), S. sciuri (MIC 50 ug/ml), R. nasimurium (MIC 10 ug/ml), A. viridans (MIC 20 ug/ml), Gram

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism S. sciuri

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ bacteria S. aureus ATC29213 (MIC 10 ug/ml), S. sciuri (MIC 50 ug/ml), R. nasimurium (MIC 10 ug/ml), A. viridans (MIC 20 ug/ml), Gram- bacteria E. coli ATC2592

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µg/mL

Target

Target Organism R. nasimurium

Source & Reference

Database Source NA

Other

Evidence Text

ctive against Gram+ bacteria S. aureus ATC29213 (MIC 10 ug/ml), S. sciuri (MIC 50 ug/ml), R. nasimurium (MIC 10 ug/ml), A. viridans (MIC 20 ug/ml), Gram- bacteria E. coli ATC25922 or O111 (MIC 50 ug/ml), K. p

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µg/mL

Target

Target Organism A. viridans

Source & Reference

Database Source NA

Other

Evidence Text

. aureus ATC29213 (MIC 10 ug/ml), S. sciuri (MIC 50 ug/ml), R. nasimurium (MIC 10 ug/ml), A. viridans (MIC 20 ug/ml), Gram- bacteria E. coli ATC25922 or O111 (MIC 50 ug/ml), K. pneumoniae (MIC 50 ug/ml), an

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism Escherichia coli ATC25922 or O111

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 50 ug/ml), R. nasimurium (MIC 10 ug/ml), A. viridans (MIC 20 ug/ml), Gram- bacteria E. coli ATC25922 or O111 (MIC 50 ug/ml), K. pneumoniae (MIC 50 ug/ml), and A. bacillus (MIC 50 uM). Updated 7/2021

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source NA

Other

Evidence Text

/ml), A. viridans (MIC 20 ug/ml), Gram- bacteria E. coli ATC25922 or O111 (MIC 50 ug/ml), K. pneumoniae (MIC 50 ug/ml), and A. bacillus (MIC 50 uM). Updated 7/2021

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism A. bacillus

Source & Reference

Database Source NA

Other

Evidence Text

Gram- bacteria E. coli ATC25922 or O111 (MIC 50 ug/ml), K. pneumoniae (MIC 50 ug/ml), and A. bacillus (MIC 50 uM). Updated 7/2021

Evidence 8 Activity

Activity

Activity Endpoint LC50

Activity Raw

LC50 < 5 µg/mL

Detail Source Activity Anticancer

Activity Measurement 5 µg/mL

Target

Cancer Type Breast Cancer

Cell Line Not Available

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2016

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.

Evidence 9 Activity

Activity

Activity Endpoint 6% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

6% Hemolysis | 64 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A novel short anionic antibacterial peptide isolated from the skin of Xenopus laevis with broad antibacterial activity and inhibitory activity against breast cancer cell. | Arch Microbiol | 2016

Evidence 10 Activity

Activity

Activity Endpoint 20% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

20% Hemolysis | 128 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A novel short anionic antibacterial peptide isolated from the skin of Xenopus laevis with broad antibacterial activity and inhibitory activity against breast cancer cell. | Arch Microbiol | 2016

Evidence 11 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Arch Microbiol. 2016 Jul 198(5):473-82.