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Peptide record

TPDB18451

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB18451
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP PD_Hemolysis
standard
No
A 6-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
CRRKKC
Physicochemical Analysis
C30H60N14O7S2
ANDEQGHILMFPSTWYV
RCK
793.02
10.58
4
0
0
+4
3.12
-1.967
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
15.76
2
Residue Composition
number
0
A
2
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C30H60N14O7S2
793.02
10.58
+4
3.12
-1.967
Evidence Records 5 records
Evidence 1 Activity

Activity

HC50
Hemolysis
92.0
Human erythrocytes:HC50=92.0 ± 9.6 µg/ml

Target

Human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Int J Mol Sci. 2020 Sep 29 21(19):7208.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
92±9.6 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 92±9.6 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity. | Int J Mol Sci | 2020
Evidence 3 Activity

Activity

IC50
Toxicity
21.3±8.2 µg/mL
Cytotoxic
IC50 | 21.3±8.2 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity. | Int J Mol Sci | 2020
Evidence 4 Activity

Activity

HC50
Toxicity
92.0
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:HC50=92.0 ± 9.6 µg/ml | Cytotoxicity: HaCat: IC50=21.3 ± 8.2 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2020 Sep 29 21(19):7208.
Evidence 5 Hemolysis

Activity

92.0
HC50
Human erythrocytes:HC50=92.0 ± 9.6 µg/ml
Hemolysis

Target

Human erythrocytes

Source & Reference

PD_Hemolysis
Int J Mol Sci. 2020 Sep 29 21(19):7208.
DRAMP4
PD_Hemolysis