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Peptide record

TPDB18416

Antibacterial Anticancer Antifungal Toxicity standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB18416
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
standard
No
A 6-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Sequence
CKRKKC
Physicochemical Analysis
C30H60N12O7S2
ANDEQGHILMFPSTWYV
K
765.00
10.32
4
0
0
+4
3.30
-1.867
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
16.34
2
Residue Composition
number
0
A
1
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C30H60N12O7S2
765.00
10.32
+4
3.30
-1.867
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
122.4±16.5 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 122.4±16.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity. | Int J Mol Sci | 2020
Evidence 2 Activity

Activity

IC50
Toxicity
33.8±3.1 µg/mL
Cytotoxic
IC50 | 33.8±3.1 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity. | Int J Mol Sci | 2020
Evidence 3 Activity

Activity

HC50
Toxicity
122.4
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:HC50=122.4 ± 16.5 µg/ml | Cytotoxicity: HaCat: IC50=33.8 ± 3.1 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2020 Sep 29 21(19):7208.