TPDB

3D PDB MODEL

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TPDB ID TPDB18311

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 45-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia, AFP-GFuse, Antifungipept, and other sources, with an available 3D structural model.

Sequence

CEKPSKFFSGPCIGSSGKTQCAYLCRRGEGLQDGNCKGLKCVCAC

FASTA

>TPDB18311|Antibacterial;Antifungal|length=45
CEKPSKFFSGPCIGSSGKTQCAYLCRRGEGLQDGNCKGLKCVCAC

Formula C196H319N59O61S8

Absent Amino Acids HMW

Common Amino Acids C

Mass 4734.53

PI 8.31

Basic Residues 7

Acidic Residues 3

Hydrophobic Residues 10

Net Charge +4

Boman Index 7.67

Hydrophobicity -0.253

Aliphatic Index 45.56

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1990

Absorbance 280nm 42.03

Polar Residues 17

number

2

A

2

R

1

N

1

D

8

C

2

E

2

Q

7

G

0

H

1

I

3

L

5

K

0

M

2

F

2

P

4

S

1

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 2 R: 2 N: 1 D: 1 C: 8 E: 2 Q: 2 G: 7 H: 0 I: 1 L: 3 K: 5 M: 0 F: 2 P: 2 S: 4 T: 1 W: 0 Y: 1 V: 1

Length

45

Formula

C196H319N59O61S8

Mass

4734.53

PI

8.31

Net Charge

+4

Boman Index

7.67

Hydrophobicity

-0.253

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Radial disc diffusion assays. A microdilution assays was also used to determined IC50. Active against F. oxysporum (IC50=23.3 ug/mL), R. solani (IC50=130.3 ug/mL), C. lunata (IC50=2.7 ug/mL), and A. alternate (IC50=22.5 ug/mL) (formation of arc-shaped inhibition zone). Updated 6/2019 7/2021

Evidence 2 Activity

Activity

Detail Source Activity Antifungal

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Radial disc diffusion assays. A microdilution assays was also used to determined IC50. Active against F. oxysporum (IC50=23.3 ug/mL), R. solani (IC50=130.3 ug/mL), C. lunata (IC50=2.7 ug/mL), and A. alternate (IC50=22.5 ug/mL) (formation of arc-shaped inhibition zone). Updated 6/2019 7/2021