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Peptide record

TPDB18294

Longicalycinin A linear analogue 4 Antibacterial Anticancer Toxicity standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB18294
Longicalycinin A linear analogue 4
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 5-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
Sequence
AYPFG
Physicochemical Analysis
C28H35N5O7
RNDCEQHILKMSTWV
AGFPY
553.62
5.94
0
0
3
-0
-1.78
0.260
20.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
269.14
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
5
C28H35N5O7
553.62
5.94
-0
-1.78
0.260
Free
L
Linear
Free
Anticancer
Synthetic Analogue of Longicalycinin A
Evidence Records 7 records
Evidence 1 Activity

Activity

IC50
IC50 = 9.53 ± 0.0014 µg/ml
Anticancer
9.53

Target

Liver Cancer
HepG-2
Liver

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 10.78 ± 0.0021 µg/ml
Anticancer
10.78

Target

Colorectal Cancer
HT-29
Colon

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020
Evidence 3 Activity

Activity

27.13% Cell death at 100 µg/ml
Anticancer

Target

Liver Cancer
HepG-2
Liver

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020
Evidence 4 Activity

Activity

75.91% Cell death at 100 µg/ml
Anticancer

Target

Colorectal Cancer
HT-29
Colon

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020
Evidence 5 Activity

Activity

48.28% Cell death
Toxicity
100 µg/mL
Cytotoxic
48.28% Cell death | 100 | µg/mL | target cell: Human skin fibroblasts

Target

Human skin fibroblasts

Source & Reference

NA
DBAASP
Structure-activity relationship studies of Longicalcynin A analogues, as anticancer cyclopeptides. | Chem Biol Interact | 2020
Evidence 6 Activity

Activity

60.88% Cell death
Toxicity
100 µg/mL
Cytotoxic
60.88% Cell death | 100 | µg/mL | target cell: Human skin fibroblasts

Target

Human skin fibroblasts

Source & Reference

NA
DBAASP
Structure-activity relationship studies of Longicalcynin A analogues, as anticancer cyclopeptides. | Chem Biol Interact | 2020
Evidence 7 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Interact. 2020 Jan 5 315:108903.