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Peptide record

TPDB18288

Antibacterial Toxicity modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
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TPDB18288
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 18-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
AXWKKXXKKXXKSAKKXG
Physicochemical Analysis
C64H114N20O14
RNDCEQHILMFPTYV
K
1387.73
11.29
7
0
3
+7
4.88
-1.433
11.11
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
396.33
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
7
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 7 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
18
C64H114N20O14
1387.73
11.29
+7
4.88
-1.433
Evidence Records 4 records
Evidence 1 Activity

Activity

35% Killing
Toxicity
15 µM
Cytotoxic
35% Killing | 15 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Effects of Hydrophobic Amino Acid Substitutions on Antimicrobial Peptide Behavior | Probiotics Antimicrob Proteins | 2018
Evidence 2 Activity

Activity

22% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
22% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of Non-natural Hydrophobic Amino Acids on the Efficacy and Properties of the Antimicrobial Peptide C18G. | Probiotics Antimicrob Proteins | 2020
Evidence 3 Activity

Activity

0% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
0% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of Non-natural Hydrophobic Amino Acids on the Efficacy and Properties of the Antimicrobial Peptide C18G. | Probiotics Antimicrob Proteins | 2020
Evidence 4 Activity

Activity

65% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
65% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of Non-natural Hydrophobic Amino Acids on the Efficacy and Properties of the Antimicrobial Peptide C18G. | Probiotics Antimicrob Proteins | 2020