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Peptide record

TPDB18257

Antibacterial Antifungal standard
22 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB18257
Antibacterial Antifungal
Anti-infective peptides
Peptipedia AFP-GFuse
standard
No
A 22-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia and AFP-GFuse, with an available 3D structural model.
Sequence
AVYLPNCDRKGFYKRKQCKPSR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C117H189N37O30S2
EHIMTW
K
2658.14
10.40
7
1
6
+6
3.38
-1.318
35.45
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
3105
1.17
7
Residue Composition
number
1
A
3
R
1
N
1
D
2
C
0
E
1
Q
1
G
0
H
0
I
1
L
4
K
0
M
1
F
2
P
1
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 1 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 4 M: 0 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
22 reviewed residue count
C117H189N37O30S2 sequence-only estimate (linear, free termini)
2658.14 sequence-only estimate (linear, free termini)
10.40 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
3.38 sequence-only estimate (linear, free termini)
-1.318 sequence-only estimate (linear, free termini)
Evidence Records 12 records
Evidence 1 Activity

Activity

IC50
Antibacterial
0.5 µM

Target

M. luteus

Source & Reference

NA

Other

active against Gram+ E-hirae (IC50 >10 uM), M. luteus (IC50 0.5 uM), S. aureus 209 P (IC50 0.8 uM), S-saprophyticus KD (IC50 >10 uM), Gram- E. coli B (IC50 8
Evidence 2 Activity

Activity

IC50
Antibacterial
0.8 µM

Target

Staphylococcus aureus 209 P

Source & Reference

NA

Other

active against Gram+ E-hirae (IC50 >10 uM), M. luteus (IC50 0.5 uM), S. aureus 209 P (IC50 0.8 uM), S-saprophyticus KD (IC50 >10 uM), Gram- E. coli B (IC50 8.8 uM), E. coli K12 (IC50 0.9 u
Evidence 3 Activity

Activity

IC50
Antibacterial
8.8 µM

Target

Escherichia coli B

Source & Reference

NA

Other

eus (IC50 0.5 uM), S. aureus 209 P (IC50 0.8 uM), S-saprophyticus KD (IC50 >10 uM), Gram- E. coli B (IC50 8.8 uM), E. coli K12 (IC50 0.9 uM), E. coli kp (IC50 4.2 uM), and fungus P. pastoris GS115 (IC50
Evidence 4 Activity

Activity

IC50
Antibacterial
0.9 µM

Target

Escherichia coli K12

Source & Reference

NA

Other

eus 209 P (IC50 0.8 uM), S-saprophyticus KD (IC50 >10 uM), Gram- E. coli B (IC50 8.8 uM), E. coli K12 (IC50 0.9 uM), E. coli kp (IC50 4.2 uM), and fungus P. pastoris GS115 (IC50 1.3 uM). AMP-IBP5 is identi
Evidence 5 Activity

Activity

IC50
Antibacterial
4.2 µM

Target

Escherichia coli kp

Source & Reference

NA

Other

saprophyticus KD (IC50 >10 uM), Gram- E. coli B (IC50 8.8 uM), E. coli K12 (IC50 0.9 uM), E. coli kp (IC50 4.2 uM), and fungus P. pastoris GS115 (IC50 1.3 uM). AMP-IBP5 is identical at the amino acid leve
Evidence 6 Activity

Activity

IC50
Antibacterial
1.3 µM

Target

P. pastoris GS115

Source & Reference

NA

Other

E. coli B (IC50 8.8 uM), E. coli K12 (IC50 0.9 uM), E. coli kp (IC50 4.2 uM), and fungus P. pastoris GS115 (IC50 1.3 uM). AMP-IBP5 is identical at the amino acid level between human, mouse, rat, pig, and cow. I
Evidence 7 Activity

Activity

IC50
Antifungal
0.5 µM

Target

M. luteus

Source & Reference

NA

Other

active against Gram+ E-hirae (IC50 >10 uM), M. luteus (IC50 0.5 uM), S. aureus 209 P (IC50 0.8 uM), S-saprophyticus KD (IC50 >10 uM), Gram- E. coli B (IC50 8
Evidence 8 Activity

Activity

IC50
Antifungal
0.8 µM

Target

Staphylococcus aureus 209 P

Source & Reference

NA

Other

active against Gram+ E-hirae (IC50 >10 uM), M. luteus (IC50 0.5 uM), S. aureus 209 P (IC50 0.8 uM), S-saprophyticus KD (IC50 >10 uM), Gram- E. coli B (IC50 8.8 uM), E. coli K12 (IC50 0.9 u
Evidence 9 Activity

Activity

IC50
Antifungal
8.8 µM

Target

Escherichia coli B

Source & Reference

NA

Other

eus (IC50 0.5 uM), S. aureus 209 P (IC50 0.8 uM), S-saprophyticus KD (IC50 >10 uM), Gram- E. coli B (IC50 8.8 uM), E. coli K12 (IC50 0.9 uM), E. coli kp (IC50 4.2 uM), and fungus P. pastoris GS115 (IC50
Evidence 10 Activity

Activity

IC50
Antifungal
0.9 µM

Target

Escherichia coli K12

Source & Reference

NA

Other

eus 209 P (IC50 0.8 uM), S-saprophyticus KD (IC50 >10 uM), Gram- E. coli B (IC50 8.8 uM), E. coli K12 (IC50 0.9 uM), E. coli kp (IC50 4.2 uM), and fungus P. pastoris GS115 (IC50 1.3 uM). AMP-IBP5 is identi
Evidence 11 Activity

Activity

IC50
Antifungal
4.2 µM

Target

Escherichia coli kp

Source & Reference

NA

Other

saprophyticus KD (IC50 >10 uM), Gram- E. coli B (IC50 8.8 uM), E. coli K12 (IC50 0.9 uM), E. coli kp (IC50 4.2 uM), and fungus P. pastoris GS115 (IC50 1.3 uM). AMP-IBP5 is identical at the amino acid leve
Evidence 12 Activity

Activity

IC50
Antifungal
1.3 µM

Target

P. pastoris GS115

Source & Reference

NA

Other

E. coli B (IC50 8.8 uM), E. coli K12 (IC50 0.9 uM), E. coli kp (IC50 4.2 uM), and fungus P. pastoris GS115 (IC50 1.3 uM). AMP-IBP5 is identical at the amino acid level between human, mouse, rat, pig, and cow. I