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Peptide record

TPDB18190

Antibacterial Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB18190
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 16-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
ASVVKKWWKGWWKLLK
Physicochemical Analysis
C104H155N25O18
RNDCEQHIMFPTY
K
2043.53
11.12
5
0
9
+5
-3.46
-0.406
91.25
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
22000
1076.57
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
2
L
5
K
0
M
0
F
0
P
1
S
0
T
4
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 5 M: 0 F: 0 P: 0 S: 1 T: 0 W: 4 Y: 0 V: 2
Chemical Descriptors
16
C104H155N25O18
2043.53
11.12
+5
-3.46
-0.406
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
50% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Optimization of Antibacterial Activity in Tibetan Swine α-Helix Peptide TP by Site-Directed Mutagenesis. | Front Microbiol | 2022
Evidence 2 Activity

Activity

90% Cytotoxicity
Toxicity
128 µM
Cytotoxic
90% Cytotoxicity | 128 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Optimization of Antibacterial Activity in Tibetan Swine α-Helix Peptide TP by Site-Directed Mutagenesis. | Front Microbiol | 2022
Evidence 3 Activity

Activity

70% Cytotoxicity
Toxicity
128 µM
Cytotoxic
70% Cytotoxicity | 128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Optimization of Antibacterial Activity in Tibetan Swine α-Helix Peptide TP by Site-Directed Mutagenesis. | Front Microbiol | 2022