Back to search

Peptide record

TPDB18188

Antibacterial Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB18188
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 16-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
ASVVKKLWKGVWKLLK
Physicochemical Analysis
C93H155N23O18
RNDCEQHIMFPTY
K
1883.40
11.12
5
0
9
+5
-0.25
0.206
133.75
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11000
584.05
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
3
L
5
K
0
M
0
F
0
P
1
S
0
T
2
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 3 K: 5 M: 0 F: 0 P: 0 S: 1 T: 0 W: 2 Y: 0 V: 3
Chemical Descriptors
16
C93H155N23O18
1883.40
11.12
+5
-0.25
0.206
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
50% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Optimization of Antibacterial Activity in Tibetan Swine α-Helix Peptide TP by Site-Directed Mutagenesis. | Front Microbiol | 2022
Evidence 2 Activity

Activity

50% Cell death
Toxicity
128 µM
Cytotoxic
50% Cell death | 128 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Optimization of Antibacterial Activity in Tibetan Swine α-Helix Peptide TP by Site-Directed Mutagenesis. | Front Microbiol | 2022
Evidence 3 Activity

Activity

50% Cell death
Toxicity
128 µM
Cytotoxic
50% Cell death | 128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Optimization of Antibacterial Activity in Tibetan Swine α-Helix Peptide TP by Site-Directed Mutagenesis. | Front Microbiol | 2022