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Peptide record

TPDB18143

Antibacterial Toxicity modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
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TPDB18143
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 18-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
AQWFAIQHXSTIAMRAIN
Physicochemical Analysis
C88H136N26O23S1
DCEGLKPYV
A
1958.27
11.05
2
0
10
+1
-1.20
0.267
87.22
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
280.86
5
Residue Composition
number
4
A
1
R
1
N
0
D
0
C
0
E
2
Q
0
G
1
H
3
I
0
L
0
K
1
M
1
F
0
P
1
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 1 I: 3 L: 0 K: 0 M: 1 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
18
C88H136N26O23S1
1958.27
11.05
+1
-1.20
0.267
Evidence Records 1 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
15.2±0.1 µM
Hemolytic Cytotoxic
50% Hemolysis | 15.2±0.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Refining the eosinophil cationic protein antibacterial pharmacophore by rational structure minimization. | J Med Chem | 2011