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Peptide record

TPDB18082

Antibacterial Antifungal Antiparasitic Antiviral Toxicity modified_plain modified
15 amino acids
Basic Information
3D PDB MODEL
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TPDB18082
Antibacterial Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP dbAMP 3.0 DRAVP 2.0
modified_plain
Yes
A 15-aa modified multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Modified, details unspecified
Sequence
ALXKTMLKKLGTMAL
Physicochemical Analysis
C68H127N17O17S2
RNDCEQHIFPSWYV
L
1518.98
10.84
3
0
8
+3
0.22
0.607
117.33
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
4
L
3
K
2
M
0
F
0
P
0
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 4 K: 3 M: 2 F: 0 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C68H127N17O17S2
1518.98
10.84
+3
0.22
0.607
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
75 µM
Hemolytic Cytotoxic
50% Hemolysis | 75 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
50 µM
Cytotoxic
50% Cytotoxicity | 50 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
In vitro activity of dermaseptin S1 derivatives against genital pathogens. | APMIS | 2010
Evidence 3 Activity

Activity

50% Cytotoxicity
Toxicity
>100 µM
Cytotoxic
50% Cytotoxicity | >100 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
In vitro activity of dermaseptin S1 derivatives against genital pathogens. | APMIS | 2010
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis and antimicrobial activity of dermaseptin S1 analogues. | Bioorg Med Chem | 2008
Evidence 5 Activity

Activity

HC50
Toxicity
75 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.20718719]human red cells:HC50=75 µM. | Cytotoxicity: [Ref.20718719]Vero cells:CC50=50 µM 293TT(embryonic human culture cells):CC50>100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
APMIS. 2010 Sep 1 118(9):674-80.