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Peptide record

TPDB18075

Antibacterial Antiparasitic Antiviral Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB18075
Antibacterial Antiparasitic Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia dbAMP 3.0 AI4AVP DRAVP 2.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Antiparasitic, Antiviral, and other sources) peptide sequence curated from Peptipedia, dbAMP 3.0, AI4AVP, and other sources, with an available 3D structural model.
Sequence
ALWTTMLKKLGKMALHAGKAALGAAADTI
Physicochemical Analysis
C133H226N36O35S2
RNCEQFPSYV
A
2953.60
10.55
5
1
17
+3
-0.18
0.524
108.28
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
186.21
3
Residue Composition
number
8
A
0
R
0
N
1
D
0
C
0
E
0
Q
3
G
1
H
1
I
5
L
4
K
2
M
0
F
0
P
0
S
3
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 3 H: 1 I: 1 L: 5 K: 4 M: 2 F: 0 P: 0 S: 0 T: 3 W: 1 Y: 0 V: 0
Chemical Descriptors
29
C133H226N36O35S2
2953.60
10.55
+3
-0.18
0.524
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In vitro activity of dermaseptin S1 derivatives against genital pathogens. | APMIS | 2010
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
20 µM
Cytotoxic
50% Cytotoxicity | 20 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
In vitro activity of dermaseptin S1 derivatives against genital pathogens. | APMIS | 2010
Evidence 3 Activity

Activity

50% Cytotoxicity
Toxicity
40 µM
Cytotoxic
50% Cytotoxicity | 40 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
In vitro activity of dermaseptin S1 derivatives against genital pathogens. | APMIS | 2010
Evidence 4 Activity

Activity

HC50
Toxicity
100 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.20718719]human red cells:HC50>100 µM. | Cytotoxicity: [Ref.20718719]Vero cells:CC50=20 µM 293TT(embryonic human culture cells):CC50=40 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
APMIS. 2010 Sep 1 118(9):674-80.