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Peptide record

TPDB18069

Z24 Z44 Antibacterial Anticancer Antiviral standard

24 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB18069

Peptide_Name

Z24 Z44

Activity

Antibacterial Anticancer Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AI4AVP

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Anticancer, and Antiviral) peptide sequence curated from Peptipedia, ACP740 _ACP240, AntiCP 2.0, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

ALSKALSKALSKALSKALSKALSK-NH2

FASTA

>TPDB18069|Antibacterial;Anticancer;Antiviral|length=24
ALSKALSKALSKALSKALSKALSK-NH2

Formula C108H200N30O31

Absent Amino Acids RNDCEQGHIMFPTWYV

Common Amino Acids ALKS

Mass 2414.96

PI 11.21

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +6

Boman Index 2.34

Hydrophobicity 0.225

Aliphatic Index 122.50

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 6

number

Amino Acid Distribution

A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 6 M: 0 F: 0 P: 0 S: 6 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C108H200N30O31

Mass

2414.96

11.21

Net Charge

Boman Index

2.34

Hydrophobicity

0.225

C_terminal_Modification

Amidation

Chirality

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antibacterial

Origin

Xenopus laevis

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=97 µg/ml

Detail Source Activity Anticancer

Activity Measurement 97 µg/mL

Target

Cancer Type Lymphoma Cancer

Cell Line U-937

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=123 µg/ml

Detail Source Activity Anticancer

Activity Measurement 123 µg/mL

Target

Cancer Type Lymphoma Cancer

Cell Line U-937

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=60 µg/ml

Detail Source Activity Anticancer

Activity Measurement 60 µg/mL

Target

Cancer Type Leukemia Cancer

Cell Line 8402

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=83 µg/ml

Detail Source Activity Anticancer

Activity Measurement 83 µg/mL

Target

Cancer Type Leukemia Cancer

Cell Line 8402

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=107 µg/ml

Detail Source Activity Anticancer

Activity Measurement 107 µg/mL

Target

Cancer Type Hematopoietic Cancer

Cell Line SSKT-1

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 6 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=109 µg/ml

Detail Source Activity Anticancer

Activity Measurement 109 µg/mL

Target

Cancer Type Hematopoietic Cancer

Cell Line SSKT-1

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 7 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=115 µg/ml

Detail Source Activity Anticancer

Activity Measurement 115 µg/mL

Target

Cancer Type Brain Tumor

Cell Line Daudi

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 8 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=143 µg/ml

Detail Source Activity Anticancer

Activity Measurement 143 µg/mL

Target

Cancer Type Leukemia Cancer

Cell Line Daudi

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 9 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=80 µg/ml

Detail Source Activity Anticancer

Activity Measurement 80 µg/mL

Target

Cancer Type Leukemia Cancer

Cell Line MLA

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 10 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=102 µg/ml

Detail Source Activity Anticancer

Activity Measurement 102 µg/mL

Target

Cancer Type Leukemia Cancer

Cell Line MLA

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 11 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=64 µg/ml

Detail Source Activity Anticancer

Activity Measurement 64 µg/mL

Target

Cancer Type Lymphoma Cancer

Cell Line Raji

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 12 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=72 µg/ml

Detail Source Activity Anticancer

Activity Measurement 72 µg/mL

Target

Cancer Type Lymphoma Cancer

Cell Line Raji

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 13 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=98 µg/ml

Detail Source Activity Anticancer

Activity Measurement 98 µg/mL

Target

Cancer Type Leukemia Cancer

Cell Line K-562

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 14 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=112 µg/ml

Detail Source Activity Anticancer

Activity Measurement 112 µg/mL

Target

Cancer Type Leukemia Cancer

Cell Line K-562

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 15 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Ewing sarcoma

Cell Line CHP-100

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 16 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Ewing sarcoma

Cell Line CHP-100

Tissue Affected Blood

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 17 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 18 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 19 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990

Evidence 20 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay Trypan blue assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1990