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Peptide record

TPDB18029

Antibacterial Antifungal Toxicity standard
55 amino acids
Basic Information
3D PDB MODEL
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TPDB18029
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 55-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.
Sequence
AKYTGKCKTKKNKCKYKNDAGKDTFIKCPKFDNKKCTKDNNKCTVDTYNNAVDCD
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C267H433N77O86S6
REQHLMSW
K
6290.20
9.50
15
7
11
+8
3.14
-1.438
23.09
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
4845
0.77
22
Residue Composition
number
3
A
0
R
7
N
7
D
6
C
0
E
0
Q
2
G
0
H
1
I
0
L
15
K
0
M
2
F
1
P
0
S
6
T
0
W
3
Y
2
V
Amino Acid Distribution
A: 3 R: 0 N: 7 D: 7 C: 6 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 15 M: 0 F: 2 P: 1 S: 0 T: 6 W: 0 Y: 3 V: 2
Chemical Descriptors
55 reviewed residue count
C267H433N77O86S6 sequence-only estimate (linear, free termini)
6290.20 sequence-only estimate (linear, free termini)
9.50 sequence-only estimate (linear, free termini)
+8 sequence-only estimate (linear, free termini)
3.14 sequence-only estimate (linear, free termini)
-1.438 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The Evolutionary Conserved ?-Core Motif Influences the Anti-Candida Activity of the Penicillium chrysogenum Antifungal Protein PAF. | Front Microbiol | 2018
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human Primary Epidermal Keratinocytes (HEK)

Target

Human Primary Epidermal Keratinocytes (HEK)

Source & Reference

NA
DBAASP
The Evolutionary Conserved ?-Core Motif Influences the Anti-Candida Activity of the Penicillium chrysogenum Antifungal Protein PAF. | Front Microbiol | 2018
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human fibroblasts

Target

Human fibroblasts

Source & Reference

NA
DBAASP
The Evolutionary Conserved ?-Core Motif Influences the Anti-Candida Activity of the Penicillium chrysogenum Antifungal Protein PAF. | Front Microbiol | 2018