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Peptide record

TPDB18022

Antibacterial Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB18022
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 16-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
AKVVKKLTKGVAKLLK
Physicochemical Analysis
C81H154N22O18
RNDCEQHIMFPSWY
K
1724.25
11.21
6
0
8
+6
4.28
0.194
140.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
3
L
6
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 3 K: 6 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
16
C81H154N22O18
1724.25
11.21
+6
4.28
0.194
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
50% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Optimization of Antibacterial Activity in Tibetan Swine α-Helix Peptide TP by Site-Directed Mutagenesis. | Front Microbiol | 2022
Evidence 2 Activity

Activity

50% Cell death
Toxicity
>128 µM
Cytotoxic
50% Cell death | >128 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Optimization of Antibacterial Activity in Tibetan Swine α-Helix Peptide TP by Site-Directed Mutagenesis. | Front Microbiol | 2022
Evidence 3 Activity

Activity

50% Cell death
Toxicity
>128 µM
Cytotoxic
50% Cell death | >128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Optimization of Antibacterial Activity in Tibetan Swine α-Helix Peptide TP by Site-Directed Mutagenesis. | Front Microbiol | 2022