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Peptide record

TPDB18006

Antibacterial Antifungal Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB18006
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.
Sequence
AKRHHGYKRKFHAKRHHGYKRKFH
Physicochemical Analysis
C142H216N54O27
NDCEQILMPSTWV
HK
3111.62
12.03
16
0
6
+11
10.48
-2.283
8.33
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
2980
95.77
2
Residue Composition
number
2
A
4
R
0
N
0
D
0
C
0
E
0
Q
2
G
6
H
0
I
0
L
6
K
0
M
2
F
0
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 6 I: 0 L: 0 K: 6 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
24
C142H216N54O27
3111.62
12.03
+11
10.48
-2.283
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.78-1.56 µg/mL

Target

C. albican ATCC MYA-2876 or ATCC 90028 or 3 more from patients

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against 5 strains C. albican ATCC MYA-2876 or ATCC 90028 or 3 more from patients (MIC 0.78-1.56 ug/ml), C-glabrata ATCC 9003 (MIC >25 ug/ml), C. krusei ATCC 6258 or HIV patient (MIC 1.56-3.1 u
Evidence 2 Activity

Activity

MIC
Antibacterial
1.56-3.1 µg/mL

Target

C. krusei ATCC 6258 or HIV patient

Source & Reference

dbAMP

Other

0028 or 3 more from patients (MIC 0.78-1.56 ug/ml), C-glabrata ATCC 9003 (MIC >25 ug/ml), C. krusei ATCC 6258 or HIV patient (MIC 1.56-3.1 ug/ml), C. parapsilosis ATCC 22019 (MIC 0.78 ug/ml), C. tropicalis ATCC 13803 and 3 strains HIV
Evidence 3 Activity

Activity

MIC
Antibacterial
0.78 µg/mL

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP

Other

brata ATCC 9003 (MIC >25 ug/ml), C. krusei ATCC 6258 or HIV patient (MIC 1.56-3.1 ug/ml), C. parapsilosis ATCC 22019 (MIC 0.78 ug/ml), C. tropicalis ATCC 13803 and 3 strains HIV patient (MIC 0.78-1.56 ug/ml), C. dubliniensi
Evidence 4 Activity

Activity

MIC
Antibacterial
0.78-1.56 µg/mL

Target

C. tropicalis ATCC 13803 and HIV patient

Source & Reference

dbAMP

Other

CC 6258 or HIV patient (MIC 1.56-3.1 ug/ml), C. parapsilosis ATCC 22019 (MIC 0.78 ug/ml), C. tropicalis ATCC 13803 and 3 strains HIV patient (MIC 0.78-1.56 ug/ml), C. dubliniensis HIV patient (MIC 3.1 ug/ml), C. glabrata HIV patient (MIC 25 ug/ml),
Evidence 5 Activity

Activity

MIC
Antibacterial
3.1 µg/mL

Target

C. dubliniensis HIV patient

Source & Reference

dbAMP

Other

IC 0.78 ug/ml), C. tropicalis ATCC 13803 and 3 strains HIV patient (MIC 0.78-1.56 ug/ml), C. dubliniensis HIV patient (MIC 3.1 ug/ml), C. glabrata HIV patient (MIC 25 ug/ml),
Evidence 6 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

C. glabrata HIV patient

Source & Reference

dbAMP

Other

3 strains HIV patient (MIC 0.78-1.56 ug/ml), C. dubliniensis HIV patient (MIC 3.1 ug/ml), C. glabrata HIV patient (MIC 25 ug/ml),
Evidence 7 Activity

Activity

MIC
Antifungal
0.78-1.56 µg/mL

Target

C. albican ATCC MYA-2876 or ATCC 90028 or 3 more from patients

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against 5 strains C. albican ATCC MYA-2876 or ATCC 90028 or 3 more from patients (MIC 0.78-1.56 ug/ml), C-glabrata ATCC 9003 (MIC >25 ug/ml), C. krusei ATCC 6258 or HIV patient (MIC 1.56-3.1 u
Evidence 8 Activity

Activity

MIC
Antifungal
1.56-3.1 µg/mL

Target

C. krusei ATCC 6258 or HIV patient

Source & Reference

dbAMP CAFPdb Antifungipept

Other

0028 or 3 more from patients (MIC 0.78-1.56 ug/ml), C-glabrata ATCC 9003 (MIC >25 ug/ml), C. krusei ATCC 6258 or HIV patient (MIC 1.56-3.1 ug/ml), C. parapsilosis ATCC 22019 (MIC 0.78 ug/ml), C. tropicalis ATCC 13803 and 3 strains HIV
Evidence 9 Activity

Activity

MIC
Antifungal
0.78 µg/mL

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP CAFPdb Antifungipept

Other

brata ATCC 9003 (MIC >25 ug/ml), C. krusei ATCC 6258 or HIV patient (MIC 1.56-3.1 ug/ml), C. parapsilosis ATCC 22019 (MIC 0.78 ug/ml), C. tropicalis ATCC 13803 and 3 strains HIV patient (MIC 0.78-1.56 ug/ml), C. dubliniensi
Evidence 10 Activity

Activity

MIC
Antifungal
0.78-1.56 µg/mL

Target

C. tropicalis ATCC 13803 and HIV patient

Source & Reference

dbAMP CAFPdb Antifungipept

Other

CC 6258 or HIV patient (MIC 1.56-3.1 ug/ml), C. parapsilosis ATCC 22019 (MIC 0.78 ug/ml), C. tropicalis ATCC 13803 and 3 strains HIV patient (MIC 0.78-1.56 ug/ml), C. dubliniensis HIV patient (MIC 3.1 ug/ml), C. glabrata HIV patient (MIC 25 ug/ml),
Evidence 11 Activity

Activity

MIC
Antifungal
3.1 µg/mL

Target

C. dubliniensis HIV patient

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC 0.78 ug/ml), C. tropicalis ATCC 13803 and 3 strains HIV patient (MIC 0.78-1.56 ug/ml), C. dubliniensis HIV patient (MIC 3.1 ug/ml), C. glabrata HIV patient (MIC 25 ug/ml),
Evidence 12 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

C. glabrata HIV patient

Source & Reference

dbAMP CAFPdb Antifungipept

Other

3 strains HIV patient (MIC 0.78-1.56 ug/ml), C. dubliniensis HIV patient (MIC 3.1 ug/ml), C. glabrata HIV patient (MIC 25 ug/ml),
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
>384 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >384 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The Antimicrobial Peptides P-113Du and P-113Tri Function against Candida albicans. | Antimicrob Agents Chemother | 2016
Evidence 14 Activity

Activity

15% Cytotoxicity
Toxicity
100 µM
Cytotoxic
15% Cytotoxicity | 100 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Modifying Antifungal Peptides as Safe Food Preservatives | J Agric Food Chem | 2025