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Peptide record

TPDB17995

Antibacterial standard
59 amino acids
Basic Information
3D PDB MODEL
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TPDB17995
Antibacterial
Anti-infective peptides
Peptipedia
standard
No
A 59-aa standard natural antibacterial peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
AKGVCKYVYPGSNGYACRYPNGEWGYIVTKSNFEATKDVIVNGWVSSLLGGGYFHGNRG
Physicochemical Analysis
C291H426N78O83S2
QM
G
6409.18
9.23
7
3
23
+3
1.81
-0.336
61.02
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
20065
313.07
19
Residue Composition
number
3
A
2
R
5
N
1
D
2
C
2
E
0
Q
11
G
1
H
2
I
2
L
4
K
0
M
2
F
2
P
4
S
2
T
2
W
6
Y
6
V
Amino Acid Distribution
A: 3 R: 2 N: 5 D: 1 C: 2 E: 2 Q: 0 G: 11 H: 1 I: 2 L: 2 K: 4 M: 0 F: 2 P: 2 S: 4 T: 2 W: 2 Y: 6 V: 6
Chemical Descriptors
59
C291H426N78O83S2
6409.18
9.23
+3
1.81
-0.336
Evidence Records 1 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Spot-om-lawn assay: Active against S. dysgalactiae LMGT 3890 or 3899 (++ small clear zone of inhibition), L. lactis IL1403 (+++ clear zone of inhibition), E. faecalis LMGT 2333 or 3088 (+ visible/diffuse inhibition), E. faecium LMGT 2763 or 2772 (+++), L. lactis IL1403 (+++), L. curvatus LMGT 2353 (++), L. garvieae LMGT 3390 (++), L. monocytogenes LMGT 2651 or 2604 (+++), L. innocua LMGT 2785 (+++), S. uberis LMGT 3912 (+++), no inhibition (-): B.cereus LMGT 2805 or ATCC 9136B, S.aureus LMGT 3023 or 3242, E.coli TG1. A synthetic version of the peptide showed a similar activity spectrum.