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Peptide record

TPDB17978

Antibacterial Toxicity modified_plain modified
14 amino acids
Basic Information
3D PDB MODEL
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TPDB17978
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 14-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
AIPWIWIXRLLRKG
Physicochemical Analysis
C80H128N22O14
NDCEQHMFSTYV
I
1622.04
12.41
3
0
8
+3
-2.85
0.443
146.43
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11000
678.16
0
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
2
L
1
K
0
M
0
F
1
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 2 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
14
C80H128N22O14
1622.04
12.41
+3
-2.85
0.443
Evidence Records 2 records
Evidence 1 Activity

Activity

4% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
4% Hemolysis | 15 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Beneficial Impacts of Incorporating the Non-Natural Amino Acid Azulenyl-Alanine into the Trp-Rich Antimicrobial Peptide buCATHL4B. | Biomolecules | 2021
Evidence 2 Activity

Activity

60% Killing
Toxicity
50 µM
Cytotoxic
60% Killing | 50 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Beneficial Impacts of Incorporating the Non-Natural Amino Acid Azulenyl-Alanine into the Trp-Rich Antimicrobial Peptide buCATHL4B. | Biomolecules | 2021