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Peptide record

TPDB17912

Antibacterial Toxicity modified_plain modified
21 amino acids
Basic Information
3D PDB MODEL
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TPDB17912
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 21-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
AGYLLGKINLKPLAKLXKKIL
Physicochemical Analysis
C106H188N26O23
RDCEQHMFSTWV
L
2194.82
10.77
5
0
11
+5
0.58
0.414
158.10
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
67.89
2
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
6
L
5
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 6 K: 5 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
21
C106H188N26O23
2194.82
10.77
+5
0.58
0.414
Evidence Records 6 records
Evidence 1 Activity

Activity

IC50
Toxicity
13.07±0.35 µM
Cytotoxic
IC50 | 13.07±0.35 | µM | target cell: Human foreskin fibroblasts Hs27

Target

Human foreskin fibroblasts Hs27

Source & Reference

NA
DBAASP
New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets. | Pharmaceutics | 2022
Evidence 2 Activity

Activity

IC90
Toxicity
29.78±0.29 µM
Cytotoxic
IC90 | 29.78±0.29 | µM | target cell: Human foreskin fibroblasts Hs27

Target

Human foreskin fibroblasts Hs27

Source & Reference

NA
DBAASP
New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets. | Pharmaceutics | 2022
Evidence 3 Activity

Activity

IC50
Toxicity
15.16±1.26 µM
Cytotoxic
IC50 | 15.16±1.26 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets. | Pharmaceutics | 2022
Evidence 4 Activity

Activity

IC90
Toxicity
34.03±1.90 µM
Cytotoxic
IC90 | 34.03±1.90 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets. | Pharmaceutics | 2022
Evidence 5 Activity

Activity

60% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
60% Hemolysis | 512 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activities and action mechanism studies of transportan 10 and its analogues against multidrug-resistant bacteria. | J Pept Sci | 2015
Evidence 6 Activity

Activity

100% Killing
Toxicity
64 µg/mL
Cytotoxic
100% Killing | 64 | µg/mL | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Antimicrobial activities and action mechanism studies of transportan 10 and its analogues against multidrug-resistant bacteria. | J Pept Sci | 2015