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Peptide record

TPDB17827

Antibacterial Anticancer Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB17827
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 34-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
AAVALLPAVLLALLAPQLGKKKHRRRPSKKKRHW
Physicochemical Analysis
C178H308N58O37
NDCEIMFTY
L
3852.77
12.89
12
0
16
+10
6.52
-0.365
115.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
142.75
2
Residue Composition
number
6
A
4
R
0
N
0
D
0
C
0
E
1
Q
1
G
2
H
0
I
7
L
6
K
0
M
0
F
3
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 6 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 2 I: 0 L: 7 K: 6 M: 0 F: 0 P: 3 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
34
C178H308N58O37
3852.77
12.89
+10
6.52
-0.365
Evidence Records 4 records
Evidence 1 Activity

Activity

30% Killing
Toxicity
10 µM
Cytotoxic
30% Killing | 10 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. | Oncotarget | 2016
Evidence 2 Activity

Activity

20% Killing
Toxicity
10 µM
Cytotoxic
20% Killing | 10 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. | Oncotarget | 2016
Evidence 3 Activity

Activity

90% Killing
Toxicity
50 µM
Cytotoxic
90% Killing | 50 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. | Oncotarget | 2016
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: HEK293: 30%Killing=10 µM HFF: 20%Killing=10 µM 90%Killing=50 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Oncotarget. 2016 Feb 2 7(5):5483-94.