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Peptide record

TPDB17790

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Neurotoxin Toxicity standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB17790
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Neurotoxin Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia dbAMP AI4AVP NTxPred2 pep-lab
standard
No
A 43-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, dbAMP, AI4AVP, and other sources, with an available 3D structural model.
Sequence
AAPCFCSGKPGRGDLWILRGTCPGGYGYTSNCYKWPNICCYPH
Physicochemical Analysis
C210H303N57O56S6
EQMV
G
4714.42
8.30
5
1
13
+3
-2.62
-0.309
40.93
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
17335
367.70
16
Residue Composition
number
2
A
2
R
2
N
1
D
6
C
0
E
0
Q
7
G
1
H
2
I
2
L
2
K
0
M
1
F
5
P
2
S
2
T
2
W
4
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 1 C: 6 E: 0 Q: 0 G: 7 H: 1 I: 2 L: 2 K: 2 M: 0 F: 1 P: 5 S: 2 T: 2 W: 2 Y: 4 V: 0
Chemical Descriptors
43
C210H303N57O56S6
4714.42
8.30
+3
-2.62
-0.309
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Acts as a gating modifier on both Kv and Nav ion channels, and also acts on blood pressure. Voltage-dependently inhibits voltage-gated potassium channels Kv3 (Kv3.1/KCNC1, Kv3.2/KCNC2 and Kv3.4/KCNC4) and slows inactivation of the voltage-gated sodium channel Nav1.7/SCN9A (PubMed:16177043, PubMed:22442564, PubMed:9506974). Inhibits all Kv3.1, Kv3.2 and Kv3.4 by about 50% when tested at a voltage of +40 mV (45%, 48% and 56%, respectively). May act by binding residues in voltage-sensing domains S3b and S4 of Kv3 (PubMed:16177043). On sodium channel, tests have been done on human Nav1.7/SCN9A (expressed in HEK293 cells) (EC(50)=3 nM) and rat SCG neurons that mostly carry Nav1.7 channels (EC(50)=300 nM) (PubMed:22442564). This toxin also reduces blood pressure (Ref.1). {ECO:0000269|PubMed:16177043, ECO:0000269|PubMed:22442564, ECO:0000269|PubMed:9506974, ECO:0000269|Ref.1}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anemonia sulcata (Mediterranean snakelocks sea anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Acts as a gating modifier on both Kv and Nav ion channels, and also acts on blood pressure. Voltage-dependently inhibits voltage-gated potassium channels Kv3 (Kv3.1/KCNC1, Kv3.2/KCNC2 and Kv3.4/KCNC4) and slows inactivation of the voltage-gated sodium channel Nav1.7/SCN9A (PubMed:16177043, PubMed:22442564, PubMed:9506974).
Delta/kappa-actitoxin-Avd4a (Delta/kappa-AITX-Avd4a) (Antihypertensive protein BDS-1) (Blood depressing substance I) (BDS-I)
sea anemone
Sea anemone type 3 (BDS) potassium channel toxin family
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Hypotensive agent Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
3D-structure Direct protein sequencing Disulfide bond Hypotensive agent Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone type 3 (BDS) potassium channel toxin family
Delta/kappa-actitoxin-Avd4a (Delta/kappa-AITX-Avd4a) (Antihypertensive protein BDS-1) (Blood depressing substance I) (BDS-I)
sea anemone