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Peptide record

TPDB17789

Antibacterial Antiviral standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB17789
Antibacterial Antiviral
Anti-infective peptides
Peptipedia
standard
No
A 32-aa standard natural multi-activity (Antibacterial and Antiviral) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
AAHLPAEFTPAVHASLDKFLASVSTVLTSKYR
Physicochemical Analysis
C157H247N41O45
NCQGIMW
A
3428.94
9.65
5
2
16
+1
3.55
0.272
94.69
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
43.45
8
Residue Composition
number
6
A
1
R
0
N
1
D
0
C
1
E
0
Q
0
G
2
H
0
I
4
L
2
K
0
M
2
F
2
P
4
S
3
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 6 R: 1 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 0 H: 2 I: 0 L: 4 K: 2 M: 0 F: 2 P: 2 S: 4 T: 3 W: 0 Y: 1 V: 3
Chemical Descriptors
32
C157H247N41O45
3428.94
9.65
+1
3.55
0.272
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

radial diffusion assays: freshly solubilized peptide was active against E. faecium, L. monocytogenes, A. baumannii, P. aeruginosa in a concentration-dependent manner. Did not inhibit S.aureus, K.pneumoniae, and E.coli (bacteriostatic to this strain) till 1000 ug/ml. Both freshly solubilized and fibril forms kill L. monocytogenes and M. tuberculosis, where freshly solubilized and acidic pH 4.5 are preferred for L. monocytogenes. Also, AG-HBA(111–142) inhibited wildtype, acyclovir-resistant HSV-1 and HSV-2 isolates as well as HCMV and MeV in a dose-dependent manner, with IC50 values around 100 µg/ml.
Evidence 2 Activity

Activity

Antiviral

Source & Reference

NA

Other

radial diffusion assays: freshly solubilized peptide was active against E. faecium, L. monocytogenes, A. baumannii, P. aeruginosa in a concentration-dependent manner. Did not inhibit S.aureus, K.pneumoniae, and E.coli (bacteriostatic to this strain) till 1000 ug/ml. Both freshly solubilized and fibril forms kill L. monocytogenes and M. tuberculosis, where freshly solubilized and acidic pH 4.5 are preferred for L. monocytogenes. Also, AG-HBA(111–142) inhibited wildtype, acyclovir-resistant HSV-1 and HSV-2 isolates as well as HCMV and MeV in a dose-dependent manner, with IC50 values around 100 µg/ml.