TPDB

3D PDB MODEL

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TPDB ID TPDB17585

Activity

Antibacterial

Activity_category_statistics

Anti-infective peptides

Database_Source

DRAMP Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural antibacterial peptide sequence curated from DRAMP and Peptipedia, with an available 3D structural model.

Sequence

QLVPLAIKIYRAWKRR

FASTA

>TPDB17585|Antibacterial|length=16
QLVPLAIKIYRAWKRR

Formula C95H159N29O19

Absent Amino Acids NDCEGHMFST

Common Amino Acids R

Mass 2011.49

PI 12.14

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +5

Boman Index 0.64

Hydrophobicity -0.263

Aliphatic Index 128.12

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 347.50

Polar Residues 2

number

2

A

3

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

2

I

2

L

2

K

0

M

0

F

1

P

0

S

0

T

1

W

1

Y

1

V

Amino Acid Distribution

A: 2 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 2 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 1 V: 1

Length

16

Formula

C95H159N29O19

Mass

2011.49

PI

12.14

Net Charge

+5

Boman Index

0.64

Hydrophobicity

-0.263

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1-4 µM

Target

Target Organism Escherichia coli ATCC 25922 or UB1005

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against E. coli ATCC 25922 or UB1005 (MIC 1-4 uM), S. pullorum C79-13 (MIC 8 uM), S. typhimurium ATCC 14028 (MIC 4 uM), S. aureus ATCC 2921

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism S. pullorum C79-13

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli ATCC 25922 or UB1005 (MIC 1-4 uM), S. pullorum C79-13 (MIC 8 uM), S. typhimurium ATCC 14028 (MIC 4 uM), S. aureus ATCC 29213 (MIC 2 uM), S. epidermidis AT

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism S. typhimurium ATCC 14028

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli ATCC 25922 or UB1005 (MIC 1-4 uM), S. pullorum C79-13 (MIC 8 uM), S. typhimurium ATCC 14028 (MIC 4 uM), S. aureus ATCC 29213 (MIC 2 uM), S. epidermidis ATCC 12228 (MIC 4 uM), and E. faecalis A

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Staphylococcus aureus ATCC 29213

Source & Reference

Database Source DRAMP

Other

Evidence Text

UB1005 (MIC 1-4 uM), S. pullorum C79-13 (MIC 8 uM), S. typhimurium ATCC 14028 (MIC 4 uM), S. aureus ATCC 29213 (MIC 2 uM), S. epidermidis ATCC 12228 (MIC 4 uM), and E. faecalis ATCC 29212 (MIC 4 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source DRAMP

Other

Evidence Text

C79-13 (MIC 8 uM), S. typhimurium ATCC 14028 (MIC 4 uM), S. aureus ATCC 29213 (MIC 2 uM), S. epidermidis ATCC 12228 (MIC 4 uM), and E. faecalis ATCC 29212 (MIC 4 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Enterococcus faecalis ATCC 29212

Source & Reference

Database Source DRAMP

Other

Evidence Text

28 (MIC 4 uM), S. aureus ATCC 29213 (MIC 2 uM), S. epidermidis ATCC 12228 (MIC 4 uM), and E. faecalis ATCC 29212 (MIC 4 uM).