TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB17584

Activity

Antibacterial

Activity_category_statistics

Anti-infective peptides

Database_Source

DRAMP Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural antibacterial peptide sequence curated from DRAMP and Peptipedia, with an available 3D structural model.

Sequence

FWQLVPLAIKIYRAWKRR

FASTA

>TPDB17584|Antibacterial|length=18
FWQLVPLAIKIYRAWKRR

Formula C115H178N32O21

Absent Amino Acids NDCEGHMST

Common Amino Acids R

Mass 2344.88

PI 12.14

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +5

Boman Index -2.34

Hydrophobicity -0.128

Aliphatic Index 113.89

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 12490

Absorbance 280nm 532.65

Polar Residues 2

number

2

A

3

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

2

I

2

L

2

K

0

M

1

F

1

P

0

S

0

T

2

W

1

Y

1

V

Amino Acid Distribution

A: 2 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 2 K: 2 M: 0 F: 1 P: 1 S: 0 T: 0 W: 2 Y: 1 V: 1

Length

18

Formula

C115H178N32O21

Mass

2344.88

PI

12.14

Net Charge

+5

Boman Index

-2.34

Hydrophobicity

-0.128

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1-2 µM

Target

Target Organism Escherichia coli ATCC 25922 or UB1005

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against E. coli ATCC 25922 or UB1005 (MIC 1-2 uM), S. pullorum C79-13 (MIC 2 uM), S. typhimurium ATCC 14028 (MIC 4 uM), S. aureus ATCC 2921

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism S. pullorum C79-13

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli ATCC 25922 or UB1005 (MIC 1-2 uM), S. pullorum C79-13 (MIC 2 uM), S. typhimurium ATCC 14028 (MIC 4 uM), S. aureus ATCC 29213 (MIC 2 uM), S. epidermidis AT

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism S. typhimurium ATCC 14028

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli ATCC 25922 or UB1005 (MIC 1-2 uM), S. pullorum C79-13 (MIC 2 uM), S. typhimurium ATCC 14028 (MIC 4 uM), S. aureus ATCC 29213 (MIC 2 uM), S. epidermidis ATCC 12228 (MIC 1 uM), and E. faecalis A

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Staphylococcus aureus ATCC 29213

Source & Reference

Database Source DRAMP

Other

Evidence Text

UB1005 (MIC 1-2 uM), S. pullorum C79-13 (MIC 2 uM), S. typhimurium ATCC 14028 (MIC 4 uM), S. aureus ATCC 29213 (MIC 2 uM), S. epidermidis ATCC 12228 (MIC 1 uM), and E. faecalis ATCC 29212 (MIC 2 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source DRAMP

Other

Evidence Text

C79-13 (MIC 2 uM), S. typhimurium ATCC 14028 (MIC 4 uM), S. aureus ATCC 29213 (MIC 2 uM), S. epidermidis ATCC 12228 (MIC 1 uM), and E. faecalis ATCC 29212 (MIC 2 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Enterococcus faecalis ATCC 29212

Source & Reference

Database Source DRAMP

Other

Evidence Text

28 (MIC 4 uM), S. aureus ATCC 29213 (MIC 2 uM), S. epidermidis ATCC 12228 (MIC 1 uM), and E. faecalis ATCC 29212 (MIC 2 uM).