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Peptide record

TPDB17579

Antibacterial Antifungal Toxicity standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB17579
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
DRAMP Peptipedia CAFPdb dbAMP
standard
No
A 6-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from DRAMP, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
SLRGCC
Physicochemical Analysis
C23H43N9O8S2
ANDEQHIKMFPTWYV
C
637.77
8.30
1
0
1
+1
-0.09
0.517
65.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
125
19.60
3
Residue Composition
number
0
A
1
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C23H43N9O8S2
637.77
8.30
+1
-0.09
0.517
Evidence Records 4 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
420 µM
Hemolytic Cytotoxic
0% Hemolysis | 420 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
RcAlb-PepII, a Synthetic Small Peptide Bioinspired in the 2S Albumin From the Seed Cake of Ricinus Communis, Is a Potent Antimicrobial Agent Against Klebsiella Pneumoniae and Candida Parapsilosis. | Biochim Biophys Acta | 2019
Evidence 2 Activity

Activity

0% Killing
Toxicity
250 µM
Cytotoxic
0% Killing | 250 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
RcAlb-PepII, a Synthetic Small Peptide Bioinspired in the 2S Albumin From the Seed Cake of Ricinus Communis, Is a Potent Antimicrobial Agent Against Klebsiella Pneumoniae and Candida Parapsilosis. | Biochim Biophys Acta | 2019
Evidence 3 Activity

Activity

21.5% Killing
Toxicity
420 µM
Cytotoxic
21.5% Killing | 420 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
RcAlb-PepII, a Synthetic Small Peptide Bioinspired in the 2S Albumin From the Seed Cake of Ricinus Communis, Is a Potent Antimicrobial Agent Against Klebsiella Pneumoniae and Candida Parapsilosis. | Biochim Biophys Acta | 2019
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31678367] RcAlb-PepII was not harmful to human erythrocytes, even at a concentration 10 times higher than the MBC and MFC for K. pneumoniae and C. parapsilosis, respectively. | Cytotoxicity: [Ref.31678367] At 420 µM concentration (10 and 16.8 times higher than the MBC and MFC for K. pneumoniae and C. parapsilosis, respectively) RcAlb-PepII reduced only in 21.5% the Vero cell viability

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta Biomembr. 2020 Feb 1 1862(2):183092. doi: 10.1016/j.bbamem.2019.183092. Epub 2019 Oct 31.