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Peptide record

TPDB17578

Proadrenomedullin N-20 terminal peptide Antibacterial Neuropeptide Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB17578
Proadrenomedullin N-20 terminal peptide
Antibacterial Neuropeptide Toxicity
Anti-infective peptides Toxicity and safety peptides Neuroactive peptides
DRAMP Peptipedia ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Neuropeptide, and Toxicity) peptide sequence curated from DRAMP, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ARLDVASEFRKKWNKWALSR
Physicochemical Analysis
C112H177N35O28
CQGHIMPTY
ARK
2461.86
11.46
6
2
9
+4
2.94
-0.955
68.50
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11000
446.82
3
Residue Composition
number
3
A
3
R
1
N
1
D
0
C
1
E
0
Q
0
G
0
H
0
I
2
L
3
K
0
M
1
F
0
P
2
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 3 M: 0 F: 1 P: 0 S: 2 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
20
C112H177N35O28
2461.86
11.46
+4
2.94
-0.955
Evidence Records 3 records
Evidence 1 Activity

Activity

Neuropeptide

Target

Calcitonin gene-related peptide type 1 receptor
Homo sapiens

Source & Reference

NA
NeuroPepV2

Other

Homo sapiens
Adrenomedullin
461
NP00061 NP00047 NP00065 NP00056 NP00052 NP01795 NP01799
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
10% Hemolysis | >256 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Proadrenomedullin N-terminal 20 peptide (PAMP) and its C-terminal 12-residue peptide, PAMP(9-20): Cell selectivity and antimicrobial mechanism | Biochem Biophys Res Commun | 2020
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic
Hemolytic_activity: [Ref.32439180]HC10 > 256 µM against sheep RBCs.Note: HC10 is the minimum peptide concentration that caused >10% hemolysis of sheep red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2020 Jun 30 527(3):744-750. doi: 10.1016/j.bbrc.2020.04.063. Epub 2020 May 18.
Additional Detail Fields 3 fields
Adrenomedullin
461
NP00061 NP00047 NP00065 NP00056 NP00052 NP01795 NP01799