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Peptide record

TPDB17577

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB17577
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
DRAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from DRAMP and Peptipedia, with an available 3D structural model.
Sequence
FRKKWNKWALSR
Physicochemical Analysis
C77H118N24O15
DCEQGHIMPTYV
K
1619.94
12.43
5
0
5
+5
-0.42
-1.533
40.83
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11000
679.04
2
Residue Composition
number
1
A
2
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
3
K
0
M
1
F
0
P
1
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 3 M: 0 F: 1 P: 0 S: 1 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
12
C77H118N24O15
1619.94
12.43
+5
-0.42
-1.533
Evidence Records 2 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
10% Hemolysis | >256 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Proadrenomedullin N-terminal 20 peptide (PAMP) and its C-terminal 12-residue peptide, PAMP(9-20): Cell selectivity and antimicrobial mechanism | Biochem Biophys Res Commun | 2020
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic
Hemolytic_activity: [Ref.32439180]HC10 > 256 µM against sheep RBCs.Note: HC10 is the minimum peptide concentration that caused >10% hemolysis of sheep red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2020 Jun 30 527(3):744-750. doi: 10.1016/j.bbrc.2020.04.063. Epub 2020 May 18.