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Peptide record

TPDB17575

Antibacterial Toxicity modified_plain modified
21 amino acids
Basic Information
3D PDB MODEL
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TPDB17575
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
DRAMP Peptipedia
modified_plain
Yes
A 21-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from DRAMP and Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
KLLKKXGKLLKKXGKLLKKXG
Physicochemical Analysis
C96H185N27O19
ARNDCEQHIMFPSTWYV
K
2021.69
11.41
9
0
6
+9
5.58
-0.643
111.43
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
6
L
9
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 6 K: 9 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C96H185N27O19
2021.69
11.41
+9
5.58
-0.643
Evidence Records 6 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
<100 µM
Hemolytic Cytotoxic
0% Hemolysis | <100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of amphipathic antimicrobial peptides using helix-destabilizing sarcosine. | J Pept Sci | 2021
Evidence 2 Activity

Activity

0% Cytotoxicity
Toxicity
<100 µM
Cytotoxic
0% Cytotoxicity | <100 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Structure-activity relationship study of amphipathic antimicrobial peptides using helix-destabilizing sarcosine. | J Pept Sci | 2021
Evidence 3 Activity

Activity

0% Cytotoxicity
Toxicity
<100 µM
Cytotoxic
0% Cytotoxicity | <100 | µM | target cell: Human lung fibroblasts TIG-3

Target

Human lung fibroblasts TIG-3

Source & Reference

NA
DBAASP
Structure-activity relationship study of amphipathic antimicrobial peptides using helix-destabilizing sarcosine. | J Pept Sci | 2021
Evidence 4 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational Design of Helix-Stabilized Antimicrobial Peptide Foldamers Containing α,α-Disubstituted Amino Acids or Side-Chain Stapling. | Chempluschem | 2020
Evidence 5 Activity

Activity

<5% Hemolysis
Toxicity
1.56 µM
Hemolytic Cytotoxic
<5% Hemolysis | 1.56 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational Design of Helix-Stabilized Antimicrobial Peptide Foldamers Containing α,α-Disubstituted Amino Acids or Side-Chain Stapling. | Chempluschem | 2020
Evidence 6 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.33369262] Peptide 2 showed no hemolytic activity up to a concentration of 100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Chempluschem. 2020 Dec 85(12):2731-2736. doi: 10.1002/cplu.202000749.